COMMD10 and SCNN1B

Number of citations of the paper that reports this interaction (PubMedID 29997525)
59

Data Source:
BioGRID (pull down)

		COMMD10	SCNN1B
Description		COMM domain containing 10	sodium channel epithelial 1 subunit beta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sodium Channel Complex Extracellular Exosome
	Molecular Function	Protein Binding	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process		Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Renal System Process Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Artery Smooth Muscle Contraction Response To Food Aldosterone Metabolic Process Erythrocyte Homeostasis Monoatomic Ion Transmembrane Transport Multicellular Organism Growth Sodium Ion Transmembrane Transport Epithelial Fluid Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Potassium Ion Homeostasis Sodium Ion Homeostasis Mucus Secretion Neutrophil-mediated Killing Of Bacterium Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin
Pathways		Neddylation	Stimuli-sensing channels Sensory perception of salty taste
Drugs			Triamterene Amiloride
Diseases			Liddle syndrome Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Ankle-brachial index ( 31388106) Asthma or chronic obstructive pulmonary disease ( 24993907) Bipolar disorder and schizophrenia ( 22688191) Inflammatory biomarkers ( 22228203) Metabolite levels (X-11787) ( 23934736)	Kidney stones ( 31729369)
Interacting Genes		5 interacting genes: COMMD1 RELA SCNN1A SCNN1B SCNN1G	14 interacting genes: ANK3 CNTN1 COMMD10 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2
Entrez ID		51397	6338
HPRD ID		16734	02861
Ensembl ID		ENSG00000145781	ENSG00000168447
Uniprot IDs		D6RJ90 Q9Y6G5	B2R812 H3BQ95 P51168
PDB IDs		8ESD 8F2R 8F2U 8P0W	6BQN 6WTH 9BLR 9BTG 9BTU
Enriched GO Terms of Interacting Partners?		Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Cellular Response To Vasopressin Cellular Response To Aldosterone Sodium Channel Complex Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Response To Aldosterone Cellular Response To Acidic PH Intracellular Sodium Ion Homeostasis Sodium Ion Import Across Plasma Membrane WW Domain Binding Response To Acidic PH Cellular Response To PH Multicellular Organismal-level Water Homeostasis Sensory Perception Of Taste Cellular Response To Peptide Hormone Stimulus Sodium Channel Activity Sodium Ion Homeostasis Response To Mineralocorticoid Response To PH Response To Steroid Hormone Response To Ketone Response To Alcohol Cellular Response To Corticosteroid Stimulus Multicellular Organismal-level Chemical Homeostasis Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Steroid Hormone Stimulus Inorganic Cation Import Across Plasma Membrane Sensory Perception Of Chemical Stimulus Inorganic Ion Homeostasis Cellular Response To Lipid Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Sodium Ion Transmembrane Transport Import Across Plasma Membrane Response To Corticosteroid Regulation Of Blood Pressure Sodium Ion Transport Response To Hormone Response To Lipid Regulation Of Body Fluid Levels Chemical Homeostasis Cellular Response To Oxygen-containing Compound External Side Of Plasma Membrane Apical Plasma Membrane Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Positive Regulation Of Cholesterol Import	Negative Regulation Of Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Sensory Perception Of Salty Taste Negative Regulation Of Potassium Ion Transport Import Into Cell Negative Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Aldosterone Sodium Channel Complex Sensory Perception Of Sour Taste Cellular Response To Vasopressin Potassium Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Response To Aldosterone Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Acidic PH Regulation Of Potassium Ion Transport Intracellular Sodium Ion Homeostasis Inorganic Cation Import Across Plasma Membrane Negative Regulation Of Monoatomic Ion Transport Response To Acidic PH Ubiquitin-protein Transferase Activity Cellular Response To PH Negative Regulation Of Transmembrane Transport Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Neuromuscular Junction Development Response To Mineralocorticoid Sodium Ion Transmembrane Transport Response To PH Import Across Plasma Membrane Regulation Of Metal Ion Transport Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Monoubiquitination Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Sodium Channel Inhibitor Activity Regulation Of Dendrite Morphogenesis Endocytosis Cellular Response To Corticosteroid Stimulus Receptor Internalization Protein K63-linked Ubiquitination
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