COMMD10 and SCNN1A

Number of citations of the paper that reports this interaction (PubMedID 29997525)
59

Data Source:
BioGRID (pull down)

		COMMD10	SCNN1A
Description		COMM domain containing 10	sodium channel epithelial 1 subunit alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Acrosomal Vesicle Cytoplasm Cytosol Plasma Membrane Cilium External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Motile Cilium Sodium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Sperm Principal Piece
	Molecular Function	Protein Binding	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process		Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Sodium Ion Homeostasis Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin
Pathways		Neddylation	Stimuli-sensing channels Sensory perception of salty taste
Drugs			Triamterene Amiloride
Diseases			Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Ankle-brachial index ( 31388106) Asthma or chronic obstructive pulmonary disease ( 24993907) Bipolar disorder and schizophrenia ( 22688191) Inflammatory biomarkers ( 22228203) Metabolite levels (X-11787) ( 23934736)	Adverse response to drug ( 30420678) Alopecia areata ( 25608926) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity (early onset extreme) ( 23563609) Primary biliary cirrhosis ( 22961000) Spleen volume ( 34128465)
Interacting Genes		5 interacting genes: COMMD1 RELA SCNN1A SCNN1B SCNN1G	17 interacting genes: COMMD10 CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2
Entrez ID		51397	6337
HPRD ID		16734	02575
Ensembl ID		ENSG00000145781	ENSG00000111319
Uniprot IDs		D6RJ90 Q9Y6G5	P37088
PDB IDs		8ESD 8F2R 8F2U 8P0W	2M3O 6BQN 6WTH
Enriched GO Terms of Interacting Partners?		Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Cellular Response To Vasopressin Cellular Response To Aldosterone Sodium Channel Complex Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Response To Aldosterone Cellular Response To Acidic PH Intracellular Sodium Ion Homeostasis Sodium Ion Import Across Plasma Membrane WW Domain Binding Response To Acidic PH Cellular Response To PH Multicellular Organismal-level Water Homeostasis Sensory Perception Of Taste Cellular Response To Peptide Hormone Stimulus Sodium Channel Activity Sodium Ion Homeostasis Response To Mineralocorticoid Response To PH Response To Steroid Hormone Response To Ketone Response To Alcohol Cellular Response To Corticosteroid Stimulus Multicellular Organismal-level Chemical Homeostasis Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Steroid Hormone Stimulus Inorganic Cation Import Across Plasma Membrane Sensory Perception Of Chemical Stimulus Inorganic Ion Homeostasis Cellular Response To Lipid Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Sodium Ion Transmembrane Transport Import Across Plasma Membrane Response To Corticosteroid Regulation Of Blood Pressure Sodium Ion Transport Response To Hormone Response To Lipid Regulation Of Body Fluid Levels Chemical Homeostasis Cellular Response To Oxygen-containing Compound External Side Of Plasma Membrane Apical Plasma Membrane Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Positive Regulation Of Cholesterol Import	Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Post-translational Protein Modification Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Potassium Ion Export Across Plasma Membrane Transmembrane Transporter Binding Protein Monoubiquitination Proteolysis Ubiquitin Protein Ligase Activity Protein Modification Process Negative Regulation Of Potassium Ion Transmembrane Transport Protein Ubiquitination Import Into Cell Sodium Ion Import Across Plasma Membrane Protein Metabolic Process Negative Regulation Of Potassium Ion Transport Catabolic Process Sensory Perception Of Salty Taste Extracellular Exosome Macromolecule Metabolic Process Biological Process Involved In Interaction With Host Cellular Response To Aldosterone Sodium Channel Complex Protein Catabolic Process Sodium Channel Inhibitor Activity Sensory Perception Of Sour Taste Cellular Response To Vasopressin Regulation Of Protein Catabolic Process Sodium Ion Transport Establishment Of Protein Localization To Vacuole Regulation Of Dendrite Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Receptor Internalization Positive Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Negative Regulation Of Monoatomic Ion Transmembrane Transport Cytosol Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Regulation Of Protein Transport Endocytosis Endosome Negative Regulation Of Sodium Ion Transport
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