TMA7 and SETD2

Data Source: HiPPIP (Novel)

		TMA7	SETD2
Name		translation machinery associated 7 homolog	SET domain containing 2, histone lysine methyltransferase
Structure		No pdb structure
GO Annotations	Cellular Component	None	Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	None	Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Trimethyltransferase Activity
	Biological Process	None	Autophagosome Assembly Immune System Process DNA Repair Mismatch Repair Chromatin Organization Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II DNA Damage Response Response To Metal Ion Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Peptidyl-lysine Trimethylation Cell Differentiation Methylation Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Endodermal Cell Differentiation Response To Alkaloid Innate Immune Response Positive Regulation Of Ossification Stem Cell Differentiation Defense Response To Virus Protein K48-linked Ubiquitination Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin
Pathways		None	PKMTs methylate histone lysines
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Feeling miserable ( 29500382 ) Inflammatory bowel disease ( 28067908 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 )	Adult body size ( 32376654 ) Basophil count ( 32888494 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol ( 24097068 30275531 ) HDL cholesterol levels ( 28334899 ) Huntington's disease progression ( 28642124 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean platelet volume ( 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Monocyte count ( 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 27863252 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Refractive error ( 32231278 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 ) White blood cell count ( 27863252 32888494 ) White blood cell count (basophil) ( 27863252 )
Novel Interactors		2 novel interactors: QRICH1 SETD2	6 novel interactors: EXOSC7 GMPPB KLHL18 NDUFAF3 TEX264 TMA7
Interacting Genes		7 interacting genes: APP CEBPA ERBB2 ERBB3 ERBB4 FBXO25 TSC22D2	10 interacting genes: ARX ATXN1 CIC H3-4 H3C1 HTT SHANK3 SIAH2 SMAD3 SPOP
Entrez ID		51372	29072
HPRD ID		13686	11043
Ensembl ID		ENSG00000232112	ENSG00000181555
Uniprot IDs		Q9Y2S6	A0A1W2PPX9 Q9BYW2
PDB IDs		Not available	2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22 6J9J 6VDB 7EA8 7EVR 7EVS 7LZB 7LZD 7LZF 7TY2 7TY3 8Q5P 8RZU 9EGZ 9EH0 9EH1 9EH2
GO Terms Enriched among Interactors		ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity Receptor Complex ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Glial Cell Development Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Protein Heterodimerization Activity Intracellular Signaling Cassette Protein Tyrosine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade Positive Regulation Of Biosynthetic Process Peripheral Nervous System Development Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression Response To Stress Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of RNA Biosynthetic Process Integrated Stress Response Signaling Regulation Of Gene Expression Basolateral Plasma Membrane Regulation Of MAPK Cascade Regulation Of Macromolecule Biosynthetic Process Synapse Organization Growth Factor Binding Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Heart Development Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Negative Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcium-mediated Signaling	Vocal Learning Learning Social Behavior Observational Learning Auditory Behavior Learning Or Memory Mechanosensory Behavior Cognition Memory Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Chromatin Binding Proteasomal Protein Catabolic Process Lung Alveolus Development