ZBTB7A and BCL6

Number of citations of the paper that reports this interaction (PMID 9927193)
27

Data Source:
HPRD (in vivo, two hybrid)

		ZBTB7A	BCL6
Gene Name		zinc finger and BTB domain containing 7A	B-cell CLL/lymphoma 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Replication Fork
	Molecular Function	DNA Binding Protein Binding Histone Acetyltransferase Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Multicellular Organismal Development Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Negative Regulation Of Cell-matrix Adhesion Germinal Center Formation Regulation Of Germinal Center Formation Negative Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Inflammatory Response Cellular Response To DNA Damage Stimulus Rho Protein Signal Transduction Spermatogenesis Negative Regulation Of Cell Proliferation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Histone Deacetylation Regulation Of Rho GTPase Activity Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response Positive Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Negative Regulation Of Cellular Senescence
Pathways
Drugs
Diseases
GWAS			B cell non-Hodgkin lymphoma ( 23749188) PR interval ( 23534349) Pulmonary function (interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		12 interactors: AR BCL6 HOMEZ KHDRBS1 RELA SP1 SP3 SP4 SUMO1 TP53 ZBTB48 ZMYND8	44 interactors: AES BCL11A BCL6B BCOR BLZF1 CDK19 CDK8 CHD3 CREBBP CUTC EP300 FBXO11 HDAC4 HDAC5 HDAC7 HDAC9 IRF4 JUN JUNB JUND KIFC3 LIMS3 MAPK1 MED17 MED6 MTA3 NCOR1 NCOR2 PELI1 PIN1 PML PPARD PRKD3 RAF1 RUNX1T1 SIAH1 SIN3A SP1 SPI1 TRAF1 WNK4 ZBTB16 ZBTB7A ZBTB7B
Entrez ID		51341	604
HPRD ID		10433	00180
Ensembl ID		ENSG00000178951	ENSG00000113916
Uniprot IDs		O95365 Q8TB76	B5B0A5 P41182
PDB IDs		2IF5 2NN2	1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Embryonic Process Involved In Female Pregnancy B Cell Differentiation Erythrocyte Differentiation Enucleate Erythrocyte Differentiation Erythrocyte Homeostasis Positive Regulation Of Histone Deacetylation Myeloid Cell Homeostasis Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Megakaryocyte Differentiation Positive Regulation Of Protein Deacetylation Liver Development B Cell Activation Definitive Hemopoiesis Positive Regulation Of Cellular Biosynthetic Process Trophectodermal Cell Differentiation Protein Localization To Nucleus Gland Development Protein Import Into Nucleus, Translocation	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated RNA Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Hemopoiesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Immune System Development Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Immune System Process DNA-templated Transcription, Initiation Response To Organic Substance Leukocyte Differentiation Chromatin Modification Cellular Protein Modification Process Developmental Process Nitrogen Compound Metabolic Process Organ Development Chromosome Organization
Tagcloud ?		acquisition actionable ar block bypassed castration conversely counteracts crpc driven elucidate facilitates identifies innovative integrated leverages mechanistically notably overcomes predictive prostate pten signature srd5a1 stratification tailored trp53 xaf1 xiap	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Difference) ?		acquisition actionable ar block bypassed castration conversely counteracts crpc driven elucidate facilitates identifies innovative integrated leverages mechanistically notably overcomes predictive prostate pten signature srd5a1 stratification tailored trp53 xaf1 xiap	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Intersection) ?