RXFP3 and RLN3

Number of citations of the paper that reports this interaction (PMID 22257012)
4

Data Source:
BioGRID (unspecified method)

		RXFP3	RLN3
Gene Name		relaxin/insulin-like family peptide receptor 3	relaxin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region
	Molecular Function	G-protein Coupled Receptor Activity G-protein Coupled Peptide Receptor Activity	G-protein Coupled Receptor Binding Hormone Activity Protein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: APP RLN3	3 interactors: RXFP1 RXFP3 RXFP4
Entrez ID		51289	117579
HPRD ID		17979	06031
Ensembl ID		ENSG00000182631
Uniprot IDs		Q9NSD7	Q8WXF3
PDB IDs			2FHW 2K1V
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing Cholesterol Metabolic Process Adult Locomotory Behavior Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Cell Recognition	G-protein Coupled Receptor Signaling Pathway Angiotensin-activated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Parturition Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytokinesis Regulation Of Cytokinesis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		alcohol autoradiography behaviours dense discrete extrahypothalamic forebrain hindbrain histochemistry hybridisation hypothalamic i5 incertus ingestive intake modulating neuroadaptive neuropeptides preferring projections r3 radioligand relaxin rewarding seeking substances sucrose voluntary washout	accompanied activate cardiogenesis cardiomyocyte cardiomyocytes certain delivery dynamic exogenous heart injury jak1 lost program purification regenerate regeneration restricted ribosome rln3a rnas secreted spared stat3 transgenic translating trauma vertebrates zebrafish
Tagcloud (Difference) ?		alcohol autoradiography behaviours dense discrete extrahypothalamic forebrain hindbrain histochemistry hybridisation hypothalamic i5 incertus ingestive intake modulating neuroadaptive neuropeptides preferring projections r3 radioligand relaxin rewarding seeking substances sucrose voluntary washout	accompanied activate cardiogenesis cardiomyocyte cardiomyocytes certain delivery dynamic exogenous heart injury jak1 lost program purification regenerate regeneration restricted ribosome rln3a rnas secreted spared stat3 transgenic translating trauma vertebrates zebrafish
Tagcloud (Intersection) ?