TRIM62 and FAIM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM62	FAIM
Description		tripartite motif containing 62	Fas apoptotic inhibitory molecule
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Immune System Process Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Viral Release From Host Cell Negative Regulation Of Viral Transcription Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Positive Regulation Of Antifungal Innate Immune Response	Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Gut microbiota (beta diversity) ( 27723756)	Blood protein levels ( 30072576) Male-pattern baldness ( 28196072)
Interacting Genes		19 interacting genes: CARD9 EAF1 EPN2 EXOSC5 FAIM GLRX PPP1R18 SKIL SMAD2 SP7 TBC1D7 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2L6 UBXN7 UTP25	10 interacting genes: CDR2L DAPP1 INCA1 LHX3 LMNA RSPH1 SPRY2 TRIM62 ZNF16 ZRANB1
Entrez ID		55223	55179
HPRD ID		07697	16874
Ensembl ID		ENSG00000116525	ENSG00000158234
Uniprot IDs		Q9BVG3	Q9NVQ4
PDB IDs			2KW1 3MX7
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Regulation Of BMP Signaling Pathway Macromolecule Catabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein K11-linked Ubiquitination Regulation Of Cellular Response To Growth Factor Stimulus Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K6-linked Ubiquitination Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleoplasm Nucleus Protein-containing Complex SMAD Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Proteolysis Phosphatase Binding Macromolecule Metabolic Process Protein Monoubiquitination Glutathione Disulfide Oxidoreductase Activity Homomeric SMAD Protein Complex TSC1-TSC2 Complex Binding Negative Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Protein Autoubiquitination Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination TSC1-TSC2 Complex	Regulation Of Programmed Cell Death Organelle Localization Regulation Of Apoptotic Process Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA Double-strand Break Attachment To Nuclear Envelope Cytoskeleton Organization Microtubule Cytoskeleton Organization Negative Regulation Of Programmed Cell Death Establishment Of Organelle Localization Negative Regulation Of Apoptotic Process Structural Constituent Of Nuclear Lamina Microtubule-based Process Cellular Response To Sodium Dodecyl Sulfate Regulation Of Phosphorylation Medial Motor Column Neuron Differentiation Ventral Spinal Cord Interneuron Specification Lung Development Prolactin Secreting Cell Differentiation Somatotropin Secreting Cell Differentiation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Lung Growth Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lens Fiber Cell Differentiation Golgi To Secretory Granule Transport Protein K29-linked Deubiquitination Positive Regulation Of Antifungal Innate Immune Response Radial Spoke Head 1 Radial Spoke Head 3 Lamin Filament Nuclear Pore Localization Ubiquitin-protein Transferase Inhibitor Activity Protein K33-linked Deubiquitination Radial Spoke Head
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