TRIM62 and UTP25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM62	UTP25
Description		tripartite motif containing 62	UTP25 small subunit processome component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Small-subunit Processome
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding RRNA Binding U3 SnoRNA Binding
	Biological Process	Immune System Process Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Viral Release From Host Cell Negative Regulation Of Viral Transcription Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Positive Regulation Of Antifungal Innate Immune Response	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Protein Catabolic Process Protein Destabilization Positive Regulation Of Embryonic Development Embryonic Organ Development Protein Localization To Nucleolus
Pathways		Interferon gamma signaling	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		19 interacting genes: CARD9 EAF1 EPN2 EXOSC5 FAIM GLRX PPP1R18 SKIL SMAD2 SP7 TBC1D7 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2L6 UBXN7 UTP25	11 interacting genes: APP CEP70 MAGEA11 MEOX2 MID2 MIPOL1 PCBP2 RUFY1 TRIM62 TRIM9 ZBTB10
Entrez ID		55223	27042
HPRD ID		07697	14535
Ensembl ID		ENSG00000116525	ENSG00000117597
Uniprot IDs		Q9BVG3	Q68CQ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Regulation Of BMP Signaling Pathway Macromolecule Catabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein K11-linked Ubiquitination Regulation Of Cellular Response To Growth Factor Stimulus Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K6-linked Ubiquitination Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleoplasm Nucleus Protein-containing Complex SMAD Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Proteolysis Phosphatase Binding Macromolecule Metabolic Process Protein Monoubiquitination Glutathione Disulfide Oxidoreductase Activity Homomeric SMAD Protein Complex TSC1-TSC2 Complex Binding Negative Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Protein Autoubiquitination Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination TSC1-TSC2 Complex	Regulation Of Viral Transcription Negative Regulation Of Viral Transcription
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