PDZD11 and CD79B

		PDZD11	CD79B
Description		PDZ domain containing 11	CD79b molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Membrane Basolateral Plasma Membrane Pore Complex Anchoring Junction Presynapse	Plasma Membrane External Side Of Plasma Membrane Membrane B Cell Receptor Complex Extracellular Exosome IgM B Cell Receptor Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Pore Complex Assembly Synaptic Vesicle Transport	Adaptive Immune Response Immune System Process Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium B Cell Differentiation B Cell Receptor Signaling Pathway
Pathways		Biotin transport and metabolism Vitamin B5 (pantothenate) metabolism Transport of vitamins, nucleosides, and related molecules Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases	CD22 mediated BCR regulation Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Polatuzumab vedotin
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS			Height ( 25282103) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: ATP2B2 ATP7A MAGI2 SIGMAR1	14 interacting genes: BLK CD19 CD3E CD5 CD79A FYN LCK LYN PTK2 PTPN6 SGTA SGTB SYK ZAP70
Entrez ID		51248	974
HPRD ID		06622	00922
Ensembl ID		ENSG00000120509	ENSG00000007312
Uniprot IDs		Q5EBL8	P40259
PDB IDs			3KG5 7WSO 7WSP 7XQ8 7XT6
Enriched GO Terms of Interacting Partners?			Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response T Cell Costimulation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Protein Tyrosine Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Regulation Of Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Immune System Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Protein Phosphorylation Regulation Of Cell Adhesion Leukocyte Activation Regulation Of Cell Adhesion Mediated By Integrin Phosphorylation Lymphocyte Proliferation Positive Regulation Of Cell Activation Mononuclear Cell Proliferation Fc Receptor Signaling Pathway Cell Activation Leukocyte Proliferation Regulation Of Leukocyte Proliferation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Positive Regulation Of Cell Adhesion Fc Receptor Mediated Stimulatory Signaling Pathway Membrane Raft T Cell Receptor Signaling Pathway Leukocyte Migration SH2 Domain Binding Regulation Of Mononuclear Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding
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