LUZP4 and FOSL2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		LUZP4	FOSL2
Name		leucine zipper protein 4	FOS like 2, AP-1 transcription factor subunit
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MRNA Transport	Cell Morphogenesis Ossification Osteoblast Differentiation Response To Hypoxia NK T Cell Differentiation Chondrocyte Differentiation Inflammatory Response To Antigenic Stimulus Keratinocyte Development Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cell Death Response To Xenobiotic Stimulus Gene Expression B Cell Differentiation T Cell Differentiation Neutrophil Differentiation Macrophage Differentiation Bone Mineralization Osteoclast Differentiation Lung Development Response To Lipopolysaccharide Collagen Metabolic Process Collagen Biosynthetic Process Multicellular Organism Growth Response To Interleukin-13 Chondrocyte Proliferation Myofibroblast Differentiation Regulation Of Multicellular Organism Growth B Cell Proliferation Glucose Homeostasis Innate Immune Response Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Smooth Muscle Tissue Development Tissue Remodeling Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue T Cell Receptor Signaling Pathway Cartilage Development Response To Glucocorticoid Bone Development Lung Connective Tissue Development Fat Pad Development Alveolar Secondary Septum Development Mucus Secretion Response To Interleukin-7 Response To Gram-positive Bacterium Insulin Metabolic Process Fat Cell Apoptotic Process Regulation Of Myofibroblast Differentiation Response To Bleomycin Response To Leukemia Inhibitory Factor
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	None
GWAS		No GWAS studies recorded	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29679657 ) Allergic rhinitis ( 30013184 ) Blond vs. brown/black hair color ( 30531825 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 23128233 ) Soluble interleukin-2 receptor subunit alpha ( 26293465 ) Systolic blood pressure ( 28135244 30578418 ) Triglyceride levels ( 32203549 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Type 1 diabetes ( 21980299 )
Interacting Genes		22 interacting genes: APPBP2 BACH2 CCDC6 CLK2 DDX39B DVL3 EMD FOS FOSL2 HSF2BP KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 LNX1 MORF4L2 NXF1 RCOR3 SRPK2 SRRM4 TLK1 TNS2	22 interacting genes: BACH2 CREB5 CYTH1 DDIT3 DNAJA3 DNMT3L EP300 FHL3 GMCL1 GOPC JUN JUNB JUND LHX8 LRIF1 LUZP4 MEOX2 NFE2L2 NME7 POLR2G SRA1 TRAF1
Entrez ID		51213	2355
HPRD ID		06589	03343
Ensembl ID		ENSG00000102021	ENSG00000075426
Uniprot IDs		Q9P127	P15408 Q9H5M2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Keratin Filament Transcription Factor AP-1 Complex Intermediate Filament Transcription Export Complex Identical Protein Binding Nucleoplasm	RNA Polymerase II Transcription Regulator Complex Transcription Factor AP-1 Complex Regulation Of RNA Metabolic Process Integrated Stress Response Signaling Protein-DNA Complex Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Response To Caloric Restriction Positive Regulation Of Nucleobase-containing Compound Metabolic Process PERK-mediated Unfolded Protein Response Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process CAMP Response Element Binding Cellular Response To Calcium Ion Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Host-mediated Activation Of Viral Transcription Transcription Cis-regulatory Region Binding Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Intracellular Signaling Cassette Negative Regulation Of Myoblast Differentiation Regulation Of T-helper 17 Cell Differentiation Host-mediated Perturbation Of Viral Transcription Double-stranded DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Calcium Ion Apoptotic Process Response To Metal Ion