FOSL2 and JUND

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		FOSL2	JUND
Description		FOS like 2, AP-1 transcription factor subunit	JunD proto-oncogene, AP-1 transcription factor subunit
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-containing Complex Protein-DNA Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Morphogenesis Ossification Osteoblast Differentiation Response To Hypoxia NK T Cell Differentiation Chondrocyte Differentiation Inflammatory Response To Antigenic Stimulus Keratinocyte Development Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cell Death Response To Xenobiotic Stimulus Gene Expression B Cell Differentiation T Cell Differentiation Neutrophil Differentiation Macrophage Differentiation Bone Mineralization Osteoclast Differentiation Lung Development Response To Lipopolysaccharide Collagen Metabolic Process Collagen Biosynthetic Process Multicellular Organism Growth Response To Interleukin-13 Chondrocyte Proliferation Myofibroblast Differentiation Regulation Of Multicellular Organism Growth B Cell Proliferation Glucose Homeostasis Innate Immune Response Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Smooth Muscle Tissue Development Tissue Remodeling Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue T Cell Receptor Signaling Pathway Cartilage Development Response To Glucocorticoid Bone Development Lung Connective Tissue Development Fat Pad Development Alveolar Secondary Septum Development Mucus Secretion Response To Interleukin-7 Response To Gram-positive Bacterium Insulin Metabolic Process Fat Cell Apoptotic Process Regulation Of Myofibroblast Differentiation Response To Bleomycin Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Circadian Rhythm Response To Light Stimulus Response To Mechanical Stimulus Gene Expression Response To Lipopolysaccharide Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Cell Cycle Cellular Response To Calcium Ion Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Forskolin
Pathways			Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29679657) Allergic rhinitis ( 30013184) Blond vs. brown/black hair color ( 30531825) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systolic blood pressure ( 28135244 30578418) Triglyceride levels ( 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 1 diabetes ( 21980299)	Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Bronchodilator response in asthma ( 25562107) Estimated glomerular filtration rate ( 30604766 31015462) Hand grip strength ( 29691431) Systemic lupus erythematosus ( 33536424) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count (monocyte) ( 28158719)
Interacting Genes		22 interacting genes: BACH2 CREB5 CYTH1 DDIT3 DNAJA3 DNMT3L EP300 FHL3 GMCL1 GOPC JUN JUNB JUND LHX8 LRIF1 LUZP4 MEOX2 NFE2L2 NME7 POLR2G SRA1 TRAF1	30 interacting genes: ACTR3 ATF3 BATF BCL6 BRCA1 CCND1 COP1 COPS5 DDIT3 EP300 ESR1 FOS FOSB FOSL2 HINFP JDP2 MAPK1 MAPK3 MAPK8 MAPK9 MDM2 MEN1 MIR9-2HG NFE2L1 NFE2L2 PPARG SLC25A12 SMAD3 SMAD4 TBP
Entrez ID		2355	3727
HPRD ID		03343	01304
Ensembl ID		ENSG00000075426	ENSG00000130522
Uniprot IDs		P15408 Q9H5M2	P17535
PDB IDs			3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF 7UCC 7UCD
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Transcription Factor AP-1 Complex Regulation Of RNA Metabolic Process Integrated Stress Response Signaling Protein-DNA Complex Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Response To Caloric Restriction Positive Regulation Of Nucleobase-containing Compound Metabolic Process PERK-mediated Unfolded Protein Response Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process CAMP Response Element Binding Cellular Response To Calcium Ion Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Host-mediated Activation Of Viral Transcription Transcription Cis-regulatory Region Binding Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Intracellular Signaling Cassette Negative Regulation Of Myoblast Differentiation Regulation Of T-helper 17 Cell Differentiation Host-mediated Perturbation Of Viral Transcription Double-stranded DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Calcium Ion Apoptotic Process Response To Metal Ion	Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Chromatin Positive Regulation Of Metabolic Process Intracellular Signal Transduction RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Nucleoplasm DNA Binding Cellular Response To Stress Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Response To Nutrient Levels Intracellular Signaling Cassette Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Negative Regulation Of Metabolic Process Response To Stress DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Enzyme Binding R-SMAD Binding DNA-templated Transcription DNA Damage Response
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