FOSL2 and CREB5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology)

		FOSL2	CREB5
Description		FOS like 2, AP-1 transcription factor subunit	cAMP responsive element binding protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding CAMP Response Element Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Morphogenesis Ossification Osteoblast Differentiation Response To Hypoxia NK T Cell Differentiation Chondrocyte Differentiation Inflammatory Response To Antigenic Stimulus Keratinocyte Development Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cell Death Response To Xenobiotic Stimulus Gene Expression B Cell Differentiation T Cell Differentiation Neutrophil Differentiation Macrophage Differentiation Bone Mineralization Osteoclast Differentiation Lung Development Response To Lipopolysaccharide Collagen Metabolic Process Collagen Biosynthetic Process Multicellular Organism Growth Response To Interleukin-13 Chondrocyte Proliferation Myofibroblast Differentiation Regulation Of Multicellular Organism Growth B Cell Proliferation Glucose Homeostasis Innate Immune Response Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Smooth Muscle Tissue Development Tissue Remodeling Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue T Cell Receptor Signaling Pathway Cartilage Development Response To Glucocorticoid Bone Development Lung Connective Tissue Development Fat Pad Development Alveolar Secondary Septum Development Mucus Secretion Response To Interleukin-7 Response To Gram-positive Bacterium Insulin Metabolic Process Fat Cell Apoptotic Process Regulation Of Myofibroblast Differentiation Response To Bleomycin Response To Leukemia Inhibitory Factor	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29679657) Allergic rhinitis ( 30013184) Blond vs. brown/black hair color ( 30531825) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systolic blood pressure ( 28135244 30578418) Triglyceride levels ( 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 1 diabetes ( 21980299)	Adolescent idiopathic scoliosis ( 31417091) Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Anxiety in major depressive disorder ( 24047446) Appendicular lean mass ( 33097823) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 29892015 30061737) Attention deficit hyperactivity disorder ( 18839057) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683) Cataracts ( 34127677) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Crohn's disease ( 23128233) Diabetic retinopathy ( 21441570) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Eosinophil percentage of granulocytes ( 27863252) Ferritin levels ( 33491795) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494 29403010) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Pre-treatment viral load in HIV-1 infection ( 31219150) Pulse pressure ( 27841878 30578418) Serum thyroid-stimulating hormone levels ( 25436638) Smoking behaviour (cigarettes smoked per day) ( 31217584) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) TPE interval (resting) ( 32386560) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 29403010 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		22 interacting genes: BACH2 CREB5 CYTH1 DDIT3 DNAJA3 DNMT3L EP300 FHL3 GMCL1 GOPC JUN JUNB JUND LHX8 LRIF1 LUZP4 MEOX2 NFE2L2 NME7 POLR2G SRA1 TRAF1	135 interacting genes: ADAMTSL4 AJUBA AKAP8L ALPP ANAPC11 ATF2 CDPF1 CERCAM CIB4 CNFN COL8A1 CYP21A2 CYSRT1 EFEMP2 FBLN1 FHL3 FOS FOSB FOSL1 FOSL2 FRS3 FST HOXA1 HSD3B7 ID3 IGFBP6 INTS11 JDP2 JUN KIFC3 KPRP KRT15 KRT31 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP19-2 KRTAP19-3 KRTAP19-5 KRTAP19-6 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1C LCE1F LCE2A LCE2C LCE4A LCE5A LGALS13 LITAF LMX1B MDFI MGAT5B MLLT6 MMADHC MTUS2 NADSYN1 NBPF19 NOTCH2NLA PCSK5 PLA2G10 PRDM14 PRR22 RBCK1 RBP3 RBPMS RCHY1 RGS17 RGS20 RIMBP3 RNF144B RNF208 SIVA1 SNAPC5 SPATA12 SPOP SPOPL SPRED1 SPRY1 SPRY2 SPRY3 SPRY4 SSC4D TP53BP1 TRAF2 TRIM23 TRIM27 TRIM42 TRIP6 TSGA10 TSPAN4 TSR2 UFSP1 UNKL WWOX ZMAT5 ZNF330
Entrez ID		2355	9586
HPRD ID		03343	09896
Ensembl ID		ENSG00000075426	ENSG00000146592
Uniprot IDs		P15408 Q9H5M2	Q02930
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Transcription Factor AP-1 Complex Regulation Of RNA Metabolic Process Integrated Stress Response Signaling Protein-DNA Complex Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Response To Caloric Restriction Positive Regulation Of Nucleobase-containing Compound Metabolic Process PERK-mediated Unfolded Protein Response Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process CAMP Response Element Binding Cellular Response To Calcium Ion Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Host-mediated Activation Of Viral Transcription Transcription Cis-regulatory Region Binding Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Intracellular Signaling Cassette Negative Regulation Of Myoblast Differentiation Regulation Of T-helper 17 Cell Differentiation Host-mediated Perturbation Of Viral Transcription Double-stranded DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Calcium Ion Apoptotic Process Response To Metal Ion	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Cytosol Protein Binding Structural Constituent Of Skin Epidermis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Identical Protein Binding Negative Regulation Of Lens Fiber Cell Differentiation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Transcription Factor AP-1 Complex Intermediate Filament Organization Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade RNA Polymerase II Transcription Regulator Complex CAMP Response Element Binding Cellular Response To Anisomycin Tissue Development Response To Anisomycin NK T Cell Differentiation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Ras Protein Signal Transduction Elastic Fiber Negative Regulation Of Epithelial Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?