CLDN18 and EHHADH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN18	EHHADH
Description		claudin 18	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Lateral Plasma Membrane Tight Junction Anchoring Junction	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Lyase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding NAD+ Binding
	Biological Process	Cell Adhesion Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Protein Localization To Nucleus Organ Growth Epithelial Fluid Transport Response To Ethanol Negative Regulation Of Bone Resorption Lung Alveolus Development Digestive Tract Development Epithelial Cell Proliferation Bicellular Tight Junction Assembly Cellular Response To Estrogen Stimulus Tight Junction Organization Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Osteoclast Development	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways		Tight junction interactions	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs			NADH
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Metabolite levels ( 23823483)	Cognitive performance ( 19734545) Major depressive disorder ( 21042317 27519822)
Interacting Genes		2 interacting genes: EHHADH PMP22	98 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES DRC4 EMP1 ERGIC1 FGF14 FUNDC1 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17
Entrez ID		51208	1962
HPRD ID		13066	06125
Ensembl ID		ENSG00000066405	ENSG00000113790
Uniprot IDs		P56856	Q08426
PDB IDs
Enriched GO Terms of Interacting Partners?		Enoyl-CoA Hydratase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Delta(3)-delta(2)-enoyl-CoA Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity Compact Myelin Establishment Of Mitotic Sister Chromatid Cohesion Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Cohesin Complex Bleb Assembly Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Myelin Assembly NAD+ Binding Peripheral Nervous System Development Long-chain Fatty Acid Biosynthetic Process Mitotic Spindle Pole Unsaturated Fatty Acid Biosynthetic Process Sister Chromatid Cohesion Mitotic Spindle Assembly	Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Negative Regulation Of Protein Localization Innate Immune Response Protein K63-linked Ubiquitination Suppression Of Viral Release By Host Regulation Of Transepithelial Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?