CYP19A1

Gene Name		cytochrome P450, family 19, subfamily A, polypeptide 1
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Iron Ion Binding Electron Carrier Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity
	Biological Process	Steroid Biosynthetic Process Estrogen Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Androgen Metabolic Process Sterol Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Prostate Gland Growth
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Estrogen biosynthesis Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Aminoglutethimide Testolactone Exemestane Letrozole Anastrozole
Diseases
GWAS		AB1-42 ( 20932310) Estradiol levels ( 22675492) Height ( 20881960 23456168 20189936) Menarche (age at onset) ( 23599027) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-protein Interactions		1 interactors: FANCG
Entrez ID		1588
HPRD ID		00488
Ensembl ID		ENSG00000137869
Uniprot IDs		A8K6W3 P11511 Q05CU4 Q8IYG4 Q8TCA4
PDB IDs		1TQA 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8
Enriched GO Terms of Interacting Partners?		Ovarian Follicle Development Ovulation Cycle Process Female Gonad Development Ovulation Cycle Development Of Primary Female Sexual Characteristics Spermatid Development Spermatid Differentiation
Tagcloud ?		4x180k benthic bioassays caeruleum customized darter disruptions dmrt1 effluent effluents esrb etheostoma foxl2 gonad grand hatching intersex mwwes oogenesis outfalls ovulation pollutant polluted rainbow rbd spermatid suite vtg