CYP19A1

Description		cytochrome P450 family 19 subfamily A member 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Metal Ion Binding Aromatase Activity Estrogen 2-hydroxylase Activity
	Biological Process	Negative Regulation Of Chronic Inflammatory Response Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process Syncytium Formation Androgen Metabolic Process Female Gonad Development Negative Regulation Of Macrophage Chemotaxis Sterol Metabolic Process Female Genitalia Development Mammary Gland Development Response To Estradiol Uterus Development Prostate Gland Growth Testosterone Biosynthetic Process Positive Regulation Of Estradiol Secretion
Pathways		Estrogen biosynthesis Endogenous sterols Defective CYP19A1 causes AEXS
Drugs		Nicotine Aminoglutethimide Estrone Testolactone Exemestane Letrozole Anastrozole 2-Methoxyestradiol Naringenin Glyphosate MPI-674 Mitapivat
Diseases		Aromatase excess syndrome 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Airway wall thickness ( 25517131) Aspartate aminotransferase levels ( 33547301) Breast cancer ( 31757997) Cerebrospinal fluid AB1-42 levels ( 20932310) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Estradiol levels ( 34255042 22675492 29325096) Estrone levels ( 29325096) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Follicle stimulating hormone levels ( 24049095) Heel bone mineral density ( 28869591 30598549) Height ( 23456168 20881960 33713608 31562340 20189936 25429064 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hormone measurements ( 24049095) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Menarche (age at onset) ( 23599027) Neutrophil percentage of white cells ( 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301 29403010) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: CRBN FANCG
Entrez ID		1588
HPRD ID		00488
Ensembl ID		ENSG00000137869
Uniprot IDs		A8K6W3 P11511 Q05CU4 Q8IYG4 Q8TCA4
PDB IDs		3EQM 3S79 3S7S 4GL5 4GL7 4KQ8 5JKV 5JKW 5JL6 5JL7 5JL9
Enriched GO Terms of Interacting Partners?
Tagcloud ?