HSPA14 and DNAJC2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, cross-linking study, cross-linking study)
HPRD (in vitro)

		HSPA14	DNAJC2
Description		heat shock protein family A (Hsp70) member 14	DnaJ heat shock protein family (Hsp40) member C2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Plasma Membrane Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	ATPase Activator Activity Chromatin Binding RNA Binding Protein Binding Hsp70 Protein Binding Histone Binding Ribosome Binding Ubiquitin-modified Histone Reader Activity
	Biological Process	Protein Folding Protein Refolding 'de Novo' Cotranslational Protein Folding	DNA Replication Chromatin Organization Regulation Of Translational Fidelity Positive Regulation Of DNA-templated Transcription 'de Novo' Cotranslational Protein Folding Regulation Of Cellular Response To Heat Negative Regulation Of DNA Biosynthetic Process
Pathways		Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		8 interacting genes: BARD1 BRCA1 CFTR DNAJC2 FAM107A OGT PAXIP1 STIP1	2 interacting genes: H2AC18 HSPA14
Entrez ID		51182	27000
HPRD ID		07021	19072
Ensembl ID		ENSG00000187522	ENSG00000105821
Uniprot IDs		Q0VDF9	Q99543
PDB IDs			2M2E 6CGH
Enriched GO Terms of Interacting Partners?		Ubiquitin-modified Histone Reader Activity Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Chromatin Organization Regulation Of Cell Cycle G2/M Phase Transition DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cell Cycle Phase Transition Response To Ionizing Radiation Regulation Of DNA Metabolic Process Regulation Of DNA Damage Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein K6-linked Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Homologous Recombination DNA Recombination Regulation Of Post-translational Protein Modification DNA Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Protein-containing Complex Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Metabolic Process Nucleus Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of MRNA 3'-end Processing Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Response To Radiation Positive Regulation Of Anion Channel Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle	'de Novo' Cotranslational Protein Folding 'de Novo' Protein Folding Protein Refolding ATP-dependent Protein Folding Chaperone
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