TUBE1 and DPAGT1

Data Source: HiPPIP (Novel)

		TUBE1	DPAGT1
Name		tubulin epsilon 1	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton GTP Binding	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Identical Protein Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Centrosome Cycle	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways		None	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective DPAGT1 causes CDG-1j, CMSTA2
Drugs		Vinblastine	None
Diseases		None	Congenital disorders of glycosylation (CDG) type I
GWAS		No GWAS studies recorded	Estimated glomerular filtration rate ( 31152163 ) Lymphocyte percentage of white cells ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 )
Novel Interactors		6 novel interactors: CDC40 DPAGT1 GOPC MTRES1 NUDC RPS20	5 novel interactors: CXCR5 ETS1 THTPA TUBE1 WDR5
Interacting Genes		None recorded	2 interacting genes: LSM8 SLC33A2
Entrez ID		51175	1798
HPRD ID		06298	01879
Ensembl ID		ENSG00000074935	ENSG00000172269
Uniprot IDs		Q9UJT0	A0A804HI18 A0A804HKZ3 Q9H3H5
PDB IDs		Not available	5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ 6JQ3
GO Terms Enriched among Interactors		UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity Negative Regulation Of Anion Channel Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity	None