DEGS1

Description		delta 4-desaturase, sphingolipid 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Membrane
	Molecular Function	Protein Binding Electron Transfer Activity Oxidoreductase Activity Isomerase Activity Sphingolipid Delta-4 Desaturase Activity Retinol Isomerase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Sphingolipid Biosynthetic Process Myelin Maintenance Ceramide Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation
Drugs
Diseases
GWAS		Red blood cell count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: DISC1
Interacting Genes		4 interacting genes: CFTR EGFR NAGPA SEMA4G
Entrez ID		8560
HPRD ID		13133
Ensembl ID		ENSG00000143753
Uniprot IDs		O15121
PDB IDs
Enriched GO Terms of Interacting Partners?		Telencephalon Cell Migration Cerebral Cortex Cell Migration Forebrain Cell Migration Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multivesicular Body, Internal Vesicle Lumen N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Cell Growth Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Positive Regulation Of Wnt Signaling Pathway Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Positive Regulation Of Enamel Mineralization Epidermal Growth Factor Binding Early Endosome Membrane Transepithelial Water Transport Regulation Of Protein Kinase C Signaling Cell Migration Secretion Of Lysosomal Enzymes Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Basolateral Plasma Membrane Positive Regulation Of Growth ERBB2-EGFR Signaling Pathway Cell Motility Radial Glia-guided Pyramidal Neuron Migration Cerebral Cortex Radial Glia-guided Migration Amelogenesis Endosome Membrane ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Salivary Gland Morphogenesis Ciliary Basal Body Regulation Of Wnt Signaling Pathway Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Response To UV-A Negative Regulation Of Cardiocyte Differentiation Golgi-associated Vesicle Membrane Eyelid Development In Camera-type Eye
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