SERPINA10 and F10

Number of citations of the paper that reports this interaction (PMID 9689066)
30

Data Source:
HPRD (in vitro)

		SERPINA10	F10
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	coagulation factor X
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Intrinsic Component Of External Side Of Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Heparin Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Phospholipid Binding
	Biological Process	Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Acrosome Reaction	Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Coagulation, Extrinsic Pathway Peptidyl-glutamic Acid Carboxylation Positive Regulation Of Cell Migration Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling
Pathways			Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Extrinsic Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins Gamma-carboxylation of protein precursors Formation of Fibrin Clot (Clotting Cascade) Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs			Antihemophilic Factor Coagulation factor VIIa Coagulation Factor IX Menadione Fondaparinux sodium Heparin Enoxaparin Gamma-Carboxy-Glutamic Acid 4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE Rivaroxaban Apixaban (2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHENESULFONAMIDE 2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE 5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE 5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE 5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-SULFONAMIDE 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE 1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide 3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE 4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE 4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE 1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE
Diseases
GWAS			Factor VII ( 17903294)
Protein-Protein Interactions		3 interactors: F10 PIAS3 PSMB7	18 interactors: APOH F3 F5 F7 F8 GAD2 GGCX HIST1H1C MGST3 PLAT PLG PRKAB1 PROS1 SERPINA10 SERPINA5 SERPINB6 SERPINB8 TFPI
Entrez ID		51156	2159
HPRD ID		09245	01966
Ensembl ID		ENSG00000140093	ENSG00000126218
Uniprot IDs		Q9UK55	P00742 Q5JVE7 Q5JVE8
PDB IDs		3F1S 3H5C 4AFX 4AJU	1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1MSX 1NFU 1NFW 1NFX 1NFY 1NL8 1P0S 1V3X 1WU1 1XKA 1XKB 1Z6E 2BMG 2BOH 2BOK 2BQ6 2BQ7 2BQW 2CJI 2D1J 2EI6 2EI7 2EI8 2FZZ 2G00 2GD4 2H9E 2J2U 2J34 2J38 2J4I 2J94 2J95 2JKH 2P16 2P3F 2P3T 2P3U 2P93 2P94 2P95 2PHB 2PR3 2Q1J 2RA0 2UWL 2UWO 2UWP 2VH0 2VH6 2VVC 2VVU 2VVV 2VWL 2VWM 2VWN 2VWO 2W26 2W3I 2W3K 2WYG 2WYJ 2XBV 2XBW 2XBX 2XBY 2XC0 2XC4 2XC5 2Y5F 2Y5G 2Y5H 2Y7X 2Y7Z 2Y80 2Y81 2Y82 3CEN 3CS7 3ENS 3FFG 3HPT 3IIT 3K9X 3KL6 3KQB 3KQC 3KQD 3KQE 3LIW 3M36 3M37 3Q3K 3SW2 3TK5 3TK6 4A7I
Enriched GO Terms of Interacting Partners?		Blood Coagulation, Extrinsic Pathway Positive Regulation Of Protein Sumoylation Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Protein Modification By Small Protein Conjugation Regulation Of Protein Sumoylation Cellular Protein Modification Process Protein Sumoylation Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Positive Regulation Of Membrane Potential Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Positive Regulation Of Protein Kinase B Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Proteolysis Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Protein Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Canonical Wnt Signaling Pathway	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation, Extrinsic Pathway Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Positive Regulation Of Blood Coagulation Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Positive Regulation Of Wound Healing Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Protein Activation Cascade Negative Regulation Of Wound Healing Platelet Degranulation Negative Regulation Of Hydrolase Activity Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Fibrinolysis Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Platelet Activation Plasminogen Activation Negative Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Fibrinolysis Response To Stimulus Secretion By Cell Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Zymogen Activation Secretion Exocytosis Positive Regulation Of Positive Chemotaxis Post-translational Protein Modification Negative Regulation Of Cellular Metabolic Process Protein Metabolic Process
Tagcloud ?			alleviating average biofeedback case chemotherapy difference experiment f3 f4 f5 given groups indicated intervention items others physical psychosomatic questionnaire reactions recruited relaxation scl scores seen serious training unhealthy
Tagcloud (Difference) ?			alleviating average biofeedback case chemotherapy difference experiment f3 f4 f5 given groups indicated intervention items others physical psychosomatic questionnaire reactions recruited relaxation scl scores seen serious training unhealthy
Tagcloud (Intersection) ?