HSD17B12 and AMBRA1

Data Source: HiPPIP (Novel)

		HSD17B12	AMBRA1
Name		hydroxysteroid 17-beta dehydrogenase 12	autophagy and beclin 1 regulator 1
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Fatty Acid Elongase Complex Membrane Extracellular Matrix	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Cytosol Cytoskeleton Focal Adhesion Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Anchoring Junction Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Fibronectin Binding Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Collagen Binding Heparin Binding Oxidoreductase Activity Very-long-chain 3-oxoacyl-CoA Reductase Activity	Protein Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding GTPase Binding Protein Phosphatase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Biosynthetic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Fatty Acid Elongation, Saturated Fatty Acid Extracellular Matrix Organization Long-chain Fatty-acyl-CoA Biosynthetic Process	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitophagy Regulation Of Transcription By RNA Polymerase II Autophagy Nervous System Development Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Ubiquitination Neural Tube Development Cell Differentiation Response To Nutrient Levels Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Mitochondrial Depolarisation Positive Regulation Of Mitophagy Positive Regulation Of Free Ubiquitin Chain Polymerization Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs	Macroautophagy
GWAS		Adult body size ( 32376654 ) Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) Birth length ( 25281659 ) Body mass index ( 25673413 26961502 29273807 ) Chronotype ( 30696823 ) Coronary artery disease ( 29212778 33020668 ) Essential hypertension (time to event) ( 32589924 ) FEV1 ( 30804560 ) Hand grip strength ( 29691431 ) HDL cholesterol levels ( 32203549 ) Lung function (forced vital capacity) ( 24929828 ) Lung function (FVC) ( 30804560 ) Morning person ( 30696823 ) Neuroblastoma ( 22941191 ) Neuroblastoma or malignant cutaneous melanoma ( 31605138 ) Sleep start time ( 33075057 ) Sporadic neuroblastoma ( 28545128 ) Type 2 diabetes ( 28566273 30297969 ) Waist circumference ( 28552196 )	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 28552196 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597 ) Immunoglobulin A ( 20694011 ) Insulin-related traits (multivariate analysis) ( 32002517 ) Normal facial asymmetry (angle of deformation score) ( 30631343 ) Schizophrenia ( 28991256 29483656 30285260 ) Selective IgA deficiency ( 27723758 )
Novel Interactors		1 novel interactors: AMBRA1	7 novel interactors: ALX4 CREM HSD17B12 KBTBD4 MTCH2 PEX11A SLC35C1
Interacting Genes		2 interacting genes: UBQLN1 UBQLN2	15 interacting genes: AKT1 BECN1 CCND1 CHUK GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MTOR RNF2 SNCA UBC UBE2D3
Entrez ID		51144	55626
HPRD ID		09989	10975
Ensembl ID		ENSG00000149084	ENSG00000110497
Uniprot IDs		Q53GQ0	A0A075B6T1 Q9C0C7
PDB IDs		Not available	8WQR
GO Terms Enriched among Interactors		Autophagosome Autophagosome Organization Autophagosome Assembly Vacuole Organization Regulation Of Macroautophagy Positive Regulation Of ERAD Pathway Autophagy Regulation Of ERAD Pathway Regulation Of Autophagy Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Organelle Assembly Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Cytoplasmic Vesicle Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Macroautophagy Negative Regulation Of G Protein-coupled Receptor Internalization Proteolysis Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Clathrin-dependent Endocytosis Cellular Response To Stress Response To Mitochondrial Depolarisation Regulation Of Protein Catabolic Process Catabolic Process Regulation Of Proteolysis Negative Regulation Of Transport Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Cellular Component Assembly Regulation Of Cellular Response To Stress Negative Regulation Of Receptor Internalization Organelle Organization Regulation Of Clathrin-dependent Endocytosis Protein Phosphatase Activator Activity Positive Regulation Of Mitophagy	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Assembly Autophagosome Maturation Autophagosome Organization Mitophagy Cellular Response To Starvation Response To Starvation Autophagy Of Mitochondrion Autophagosome Cellular Response To Nutrient Levels Macroautophagy Vacuole Organization Autophagosome Membrane Phospholipid Binding Response To Nutrient Levels Protein-containing Complex Disassembly Autophagy Ubiquitin Protein Ligase Binding Response To Iron(II) Ion Response To Iron Ion Cellular Response To Stress Beta-tubulin Binding Cellular Response To Amino Acid Starvation GABA Receptor Binding Response To Amino Acid Starvation Organelle Assembly Cellular Response To Copper Ion Cytoplasmic Vesicle Negative Regulation Of Catabolic Process Catabolic Process Negative Regulation Of Lysosome Organization Cellular Response To Oxygen-glucose Deprivation Negative Regulation Of Autophagy Response To Copper Ion Negative Regulation Of Macroautophagy Microtubule Binding Organelle Organization Endomembrane System Regulation Of Generation Of Precursor Metabolites And Energy Response To Stress Organelle Membrane Cellular Response To Decreased Oxygen Levels Response To Vitamin E Generation Of Precursor Metabolites And Energy Cellular Response To Oxygen Levels Response To Metal Ion Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Mitochondrial ATP Synthesis Coupled Electron Transport Microtubule