HSD17B12

Description		hydroxysteroid 17-beta dehydrogenase 12
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Fatty Acid Elongase Complex Membrane Extracellular Matrix
	Molecular Function	Fibronectin Binding Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Collagen Binding Heparin Binding Oxidoreductase Activity Very-long-chain 3-oxoacyl-CoA Reductase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Biosynthetic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Fatty Acid Elongation, Saturated Fatty Acid Extracellular Matrix Organization Long-chain Fatty-acyl-CoA Biosynthetic Process
Pathways		Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Birth length ( 25281659) Body mass index ( 25673413 26961502 29273807) Chronotype ( 30696823) Coronary artery disease ( 29212778 33020668) Essential hypertension (time to event) ( 32589924) FEV1 ( 30804560) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Morning person ( 30696823) Neuroblastoma ( 22941191) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Sleep start time ( 33075057) Sporadic neuroblastoma ( 28545128) Type 2 diabetes ( 28566273 30297969) Waist circumference ( 28552196)
Novel Interacting Genes		1 novel interacting genes: AMBRA1
Interacting Genes		2 interacting genes: UBQLN1 UBQLN2
Entrez ID		51144
HPRD ID		09989
Ensembl ID		ENSG00000149084
Uniprot IDs		Q53GQ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagosome Organization Autophagosome Assembly Vacuole Organization Regulation Of Macroautophagy Positive Regulation Of ERAD Pathway Autophagy Regulation Of ERAD Pathway Regulation Of Autophagy Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Organelle Assembly Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Cytoplasmic Vesicle Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Macroautophagy Negative Regulation Of G Protein-coupled Receptor Internalization Proteolysis Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Clathrin-dependent Endocytosis Cellular Response To Stress Response To Mitochondrial Depolarisation Regulation Of Protein Catabolic Process Catabolic Process Regulation Of Proteolysis Negative Regulation Of Transport Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Cellular Component Assembly Regulation Of Cellular Response To Stress Negative Regulation Of Receptor Internalization Organelle Organization Regulation Of Clathrin-dependent Endocytosis Protein Phosphatase Activator Activity Positive Regulation Of Mitophagy
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