PHF11 and AGPAT2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PHF11	AGPAT2
Description		PHD finger protein 11	1-acylglycerol-3-phosphate O-acyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Acyltransferase Activity
	Biological Process		Positive Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Epidermis Development Phospholipid Biosynthetic Process Response To Xenobiotic Stimulus CDP-diacylglycerol Biosynthetic Process Triglyceride Biosynthetic Process
Pathways			Synthesis of PA Neutrophil degranulation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases			Congenital generalized lipodystrophy (CGL)
GWAS		Breastfeeding duration ( 25475840) Cardiac hypertrophy ( 21348951) Lipoprotein (a) levels ( 30108283) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: AGPAT2 CSNK2B LSM8 MCPH1 NUTF2 PIAS4 SDCBP SPATC1L TEKT4 TRIM14 TRIM41	6 interacting genes: ABCG8 ANKRD28 GMPS PHF11 PHRF1 SLC23A2
Entrez ID		51131	10555
HPRD ID		08480	04373
Ensembl ID		ENSG00000136147	ENSG00000169692
Uniprot IDs		B4DDL5 Q9UIL8	A0A024R8F9 O15120
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Identical Protein Binding Regulation Of Cytokine-mediated Signaling Pathway	GMP Synthase (glutamine-hydrolyzing) Activity GMP Synthase Activity L-ascorbic Acid Transmembrane Transport L-ascorbic Acid Transmembrane Transporter Activity L-ascorbate:sodium Symporter Activity Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Absorption ATP-binding Cassette (ABC) Transporter Complex Purine Nucleobase Biosynthetic Process L-ascorbic Acid Metabolic Process Protein Serine/threonine Phosphatase Complex Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Intestinal Lipid Absorption Intestinal Lipid Absorption Regulation Of Intestinal Absorption GMP Biosynthetic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Cellular Response To Ethanol Apical Plasma Membrane Positive Regulation Of Dendrite Extension Vitamin Transmembrane Transport RNA Polymerase Binding
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