METTL9 and CHRM4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		METTL9	CHRM4
Description		methyltransferase 9, His-X-His N1(pi)-histidine	cholinergic receptor muscarinic 4
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity Protein-L-histidine N-pros-methyltransferase Activity	G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity
	Biological Process	Methylation	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion
Pathways			Muscarinic acetylcholine receptors G alpha (i) signalling events
Drugs			Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Serum immune biomarker levels ( 32066700) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		3 interacting genes: CHMP6 CHRM4 MYG1	22 interacting genes: B2M CBFA2T3 CD59 CD81 CFTR EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 QSOX1 RAB3A RHBDD2 RTN4 SLC60A1 SMIM7 SNCA SYN2 TM7SF2 TSPAN7 YIPF3
Entrez ID		51108	1132
HPRD ID		16839	00330
Ensembl ID		ENSG00000197006	ENSG00000180720
Uniprot IDs		Q9H1A3	P08173
PDB IDs		7Y9C 7YF2 7YF3 7YF4 8GZE 8GZF	5DSG 6D9H 6KP6 7LD3 7LD4 7TRK 7TRP 7TRQ 7TRS 7V68 7V69 7V6A 8E9X 8FX5 8IYH 8IYW 8JER 8JHN
Enriched GO Terms of Interacting Partners?		ESCRT III Complex Assembly G Protein-coupled Acetylcholine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Flavin-dependent Sulfhydryl Oxidase Activity Thiol Oxidase Activity Mitochondrial Disulfide Relay System Protein-disulfide Reductase Activity Locomotory Exploration Behavior Exploration Behavior 3'-5'-RNA Exonuclease Activity Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Plasma Membrane Repair Mitotic Cytokinetic Process ESCRT III Complex Regulation Of Signaling Receptor Activity Multivesicular Body Membrane Viral Budding From Plasma Membrane Negative Regulation Of Signaling Receptor Activity Multivesicular Body Organization Amphisome Membrane Late Endosome To Lysosome Transport Lysosomal Membrane Organization Vesicle Fusion With Vacuole Kinetochore Microtubule Viral Budding Regulation Of Exosomal Secretion Negative Regulation Of ERBB Signaling Pathway Vesicle Budding From Membrane Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Tyrosine Kinase Activity Multivesicular Body Assembly Midbody Abscission Regulation Of Spindle Assembly Multivesicular Body-lysosome Fusion Regulation Of Protein Tyrosine Kinase Activity Late Endosome To Vacuole Transport Cytokinetic Process Acetylcholine Receptor Signaling Pathway Mitochondrial RNA Metabolic Process Membrane Fission Regulation Of Mitotic Spindle Organization Endosome Transport Via Multivesicular Body Sorting Pathway	Membrane Neurotransmitter Secretion Regulation Of Chaperone-mediated Autophagy Golgi Membrane Receptor Internalization Synaptic Vesicle Clustering Positive Regulation Of Exocytosis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Protein Localization Vesicle-mediated Transport In Synapse Endoplasmic Reticulum Membrane Neurotransmitter Transport Transport Vesicle Negative Regulation Of Autophagy Regulated Exocytosis Positive Regulation Of T Cell Cytokine Production Response To Iron Ion Positive Regulation Of Transport Regulation Of T Cell Cytokine Production MHC Class II Protein Complex Binding Leukocyte Mediated Immunity Amyloid Fibril Formation Regulation Of Cytokine Production Involved In Immune Response Lymphocyte Mediated Immunity Golgi Apparatus Regulation Of Aerobic Respiration Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macrophage Fusion Vesicle-mediated Transport Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Cholesterol Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Autophagy Positive Regulation Of Lipid Kinase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Synaptic Vesicle Calcium-ion Regulated Exocytosis Regulation Of Presynaptic Dense Core Granule Exocytosis Regulation Of Vesicle Fusion Synaptic Vesicle Transport Terminal Bouton Signal Release Vesicle Localization Synaptic Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Membrane
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