CYSLTR2 and ATP5MC2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CYSLTR2	ATP5MC2
Description		cysteinyl leukotriene receptor 2	ATP synthase membrane subunit c locus 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting ATP Synthase Complex
	Molecular Function	Cysteinyl Leukotriene Receptor Activity G Protein-coupled Receptor Activity Galanin Receptor Activity Leukotriene Receptor Activity Protein Binding	Protein Binding Lipid Binding Proton Transmembrane Transporter Activity
	Biological Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway	Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Transmembrane Transport
Pathways		Leukotriene receptors G alpha (q) signalling events G alpha (s) signalling events LTC4-CYSLTR mediated IL4 production	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs		Nedocromil Leukotriene C4 Leukotriene D4
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Systemic juvenile idiopathic arthritis ( 27927641)	Appendicular lean mass ( 33097823)
Interacting Genes		19 interacting genes: ATP5MC2 DBI ENO1 GNAS GRIK1 HSP90B1 KRTAP1-1 LNX1 MTUS2 NCKIPSD PCDH9 PCMT1 RNASEK RNF144A RTN4 SVOP TTC19 YIPF6 YWHAE	4 interacting genes: ATP13A2 CYSLTR2 TDP2 XRN1
Entrez ID		57105	517
HPRD ID		09293	04429
Ensembl ID		ENSG00000152207	ENSG00000135390
Uniprot IDs		A4ZKH2 Q5KU17 Q9NS75	Q06055
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway	Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Manganese Ion Binding 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Cellular Response To Puromycin Cellular Response To Cycloheximide Cysteinyl Leukotriene Receptor Activity Nuclease Activity Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Spermine Transport P-type Transmembrane Transporter Activity Leukotriene Receptor Activity Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Regulation Of Autophagosome Size 5'-3' RNA Exonuclease Activity Leukotriene Signaling Pathway Negative Regulation Of Lysosomal Protein Catabolic Process Cupric Ion Binding Response To Cycloheximide Polyamine Transmembrane Transport Galanin Receptor Activity Regulation Of Chaperone-mediated Autophagy G-quadruplex RNA Binding Cellular Response To Manganese Ion G-quadruplex DNA Binding ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Neuronal Cell Body 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion Histone MRNA Catabolic Process RRNA Catabolic Process Regulation Of Exosomal Secretion Cellular Response To Zinc Ion Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Phosphatidic Acid Binding Histone MRNA Metabolic Process Phosphatidylinositol-3,5-bisphosphate Binding Multivesicular Body Membrane Negative Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process
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