RPS27L and ZRSR2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		RPS27L	ZRSR2
Description		ribosomal protein S27 like	zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Ribosome Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex U2AF Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Zinc Ion Binding Translation Activator Activity Metal Ion Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Ribosomal Small Subunit Assembly Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Translation	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Refractive error ( 32231278) Serum metabolite levels ( 23093944)
Interacting Genes		3 interacting genes: CLIP4 HFM1 ZRSR2	23 interacting genes: APP CCNL1 CLK1 CLK2 DSCR9 DVL3 KHDC4 LUC7L2 PRPF6 REP15 RPS27L SDCBP2 SPATS2L SRPK2 SRRM4 SRSF1 SRSF2 SRSF5 SSX2IP TEPSIN TNFAIP8L1 U2AF1 U2AF2
Entrez ID		51065	8233
HPRD ID		18003	02068
Ensembl ID		ENSG00000185088	ENSG00000169249
Uniprot IDs		Q71UM5	A0A8I5KSD0 Q15696
PDB IDs
Enriched GO Terms of Interacting Partners?		Pre-mRNA 3'-splice Site Binding U2AF Complex U12-type Spliceosomal Complex Nucleic Acid Binding Microtubule Plus-end Binding Microtubule Plus-end Reciprocal Meiotic Recombination Resolution Of Meiotic Recombination Intermediates DNA Helicase Activity Homologous Recombination Spliceosomal Complex Assembly	Regulation Of RNA Splicing Nuclear Speck Protein-RNA Complex Assembly RNA Splicing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Metabolic Process MRNA Splice Site Recognition RNA Binding RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein-containing Complex Assembly Spliceosomal Complex Regulation Of MRNA Metabolic Process Protein-containing Complex Organization RNA Splicing, Via Transesterification Reactions MRNA Binding RS Domain Binding Positive Regulation Of RNA Splicing Pre-mRNA 3'-splice Site Binding U2AF Complex Spliceosomal Complex Assembly RNA Metabolic Process Protein Kinase B Binding Cellular Component Assembly MRNA Splicing, Via Spliceosome Nucleus Catalytic Step 2 Spliceosome U2-type Prespliceosome Protein Serine/threonine/tyrosine Kinase Activity Liver Regeneration Neuron Maturation Nucleoplasm Nucleic Acid Binding Nucleic Acid Metabolic Process Frizzled Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glucose Transporter Complex Coated Vesicle Membrane
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