DESI2 and COQ8A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DESI2	COQ8A
Description		desumoylating isopeptidase 2	coenzyme Q8A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Mitochondrion Membrane Extrinsic Component Of Mitochondrial Inner Membrane Mitochondrial Membrane
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity ADP Binding
	Biological Process	Proteolysis Macromolecule Depalmitoylation	Protein Phosphorylation Ubiquinone Biosynthetic Process Phosphorylation
Pathways			Ubiquinol biosynthesis
Drugs			Fostamatinib
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Coenzyme Q10 deficiency
GWAS
Interacting Genes		11 interacting genes: ARFIP1 BNIP2 COQ8A MYG1 NFU1 PBX3 PLIN2 SEMA3G SH3GLB1 SPART THAP7	27 interacting genes: ABHD5 AGTRAP CCDC34 CMTM4 CMTM5 CMTM6 COQ9 DESI2 DTX2 JOSD2 LDAF1 MAL2 MRM1 MTIF3 ORMDL3 PBX3 RABAC1 REEP6 RPRM SH3GLB1 SMPD2 STX10 TFIP11 TMCO2 TMEM239 TPD52L2 UBC
Entrez ID		51029	56997
HPRD ID		15153	07375
Ensembl ID		ENSG00000121644	ENSG00000163050
Uniprot IDs		Q9BSY9	Q8NI60
PDB IDs			4PED 5I35 7UDP 7UDQ
Enriched GO Terms of Interacting Partners?		Lipid Droplet Lipid Droplet Organization Cellular Response To Glucose Starvation Posterior Compartment Specification Anterior Compartment Pattern Formation Midbody Negative Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axonogenesis Negative Regulation Of Retrograde Transport, Endosome To Golgi Protein Localization To Vacuolar Membrane
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