BOLA1 and BIRC7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BOLA1	BIRC7
Description		bolA family member 1	baculoviral IAP repeat containing 7
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GO Annotations	Cellular Component	Mitochondrion Iron-sulfur Cluster Assembly Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Peptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly Cell Redox Homeostasis	Lens Development In Camera-type Eye Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Regulation Of Natural Killer Cell Apoptotic Process
Pathways			Regulation of MITF-M-dependent genes involved in apoptosis
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: APP BIRC2 BIRC7 C1orf94 GLRX5 HDX TXNRD3 XIAP ZNF572	37 interacting genes: AURKC BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 DDX6 DIABLO FAM124B GTF2A1 HTRA2 KANK2 LCOR LMO4 NTAQ1 PHF1 POLR1C PRR35 PSMB1 PTCD3 QARS1 SOX5 TEPSIN TLE5 TNPO2 TSGA10IP TTPA UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2I UBE2K USP2 VPS37C XAF1
Entrez ID		51027	79444
HPRD ID		13036	05761
Ensembl ID		ENSG00000178096	ENSG00000101197
Uniprot IDs		Q9Y3E2	Q96CA5
PDB IDs		5LCI	1OXN 1OXQ 1OY7 1TW6 2I3H 2I3I 3F7G 3F7H 3F7I 3GT9 3GTA 3UW5 4AUQ
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of JNK Cascade Copper Ion Homeostasis Peptidase Inhibitor Activity Regulation Of JNK Cascade Protein Serine/threonine Kinase Binding Regulation Of Protein Polyubiquitination Regulation Of Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Cell Redox Homeostasis Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Canonical NF-kappaB Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Natural Killer Cell Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Activity Apoptotic Process Cell Death Positive Regulation Of Protein Modification Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Inflammatory Response Response To CAMP Programmed Cell Death FBXO Family Protein Binding Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Negative Regulation Of Cytokine-mediated Signaling Pathway Inorganic Ion Homeostasis Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Response To Cytokine Stimulus Protein-folding Chaperone Binding Regulation Of Innate Immune Response Positive Regulation Of Protein K48-linked Ubiquitination Regulation Of Cell Cycle Regulation Of Non-canonical NF-kappaB Signal Transduction	Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Metabolic Process Macromolecule Catabolic Process Fibroblast Apoptotic Process Iron-sulfur Cluster Assembly Complex Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Neuron Apoptotic Process Nucleus Cysteine-type Endopeptidase Activity Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Iron-sulfur Cluster Assembly Execution Phase Of Apoptosis Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Staurosporine Cytosol Negative Regulation Of Biosynthetic Process Glial Cell Apoptotic Process Protein Maturation Post-translational Protein Modification Response To Interferon-beta Response To Anesthetic Negative Regulation Of Metabolic Process Cell Redox Homeostasis Protein Binding Negative Regulation Of Macromolecule Metabolic Process Leukocyte Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Cysteine-type Peptidase Activity Response To Cobalt Ion Ubiquitin-protein Transferase Activity [2Fe-2S] Cluster Assembly CD40 Receptor Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Intracellular Iron Ion Homeostasis Protein Modification Process Positive Regulation Of Neuron Apoptotic Process Catabolic Process Apoptotic Process Intrinsic Apoptotic Signaling Pathway Histone Methyltransferase Binding Negative Regulation Of RNA Metabolic Process Protein Processing Protein Poly-ADP-ribosylation Programmed Cell Death
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