BOLA1 and TXNRD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BOLA1	TXNRD3
Description		bolA family member 1	thioredoxin reductase 3
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GO Annotations	Cellular Component	Mitochondrion Iron-sulfur Cluster Assembly Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding	Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Flavin Adenine Dinucleotide Binding
	Biological Process	Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly Cell Redox Homeostasis	Spermatogenesis Cell Differentiation Cell Redox Homeostasis Cellular Oxidant Detoxification
Pathways
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: APP BIRC2 BIRC7 C1orf94 GLRX5 HDX TXNRD3 XIAP ZNF572	9 interacting genes: ANKRD36B BOLA1 BOLA2 BOLA2B CINP CTNNA3 FHL2 PACRGL SNAP29
Entrez ID		51027	114112
HPRD ID		13036
Ensembl ID		ENSG00000178096	ENSG00000197763
Uniprot IDs		Q9Y3E2	B4DRZ5 Q86VQ6
PDB IDs		5LCI	3H8Q
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of JNK Cascade Copper Ion Homeostasis Peptidase Inhibitor Activity Regulation Of JNK Cascade Protein Serine/threonine Kinase Binding Regulation Of Protein Polyubiquitination Regulation Of Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Cell Redox Homeostasis Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Canonical NF-kappaB Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Natural Killer Cell Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Activity Apoptotic Process Cell Death Positive Regulation Of Protein Modification Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Inflammatory Response Response To CAMP Programmed Cell Death FBXO Family Protein Binding Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Negative Regulation Of Cytokine-mediated Signaling Pathway Inorganic Ion Homeostasis Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Response To Cytokine Stimulus Protein-folding Chaperone Binding Regulation Of Innate Immune Response Positive Regulation Of Protein K48-linked Ubiquitination Regulation Of Cell Cycle Regulation Of Non-canonical NF-kappaB Signal Transduction	Iron-sulfur Cluster Assembly Complex Iron-sulfur Cluster Assembly Cell Redox Homeostasis Intracellular Iron Ion Homeostasis [2Fe-2S] Cluster Assembly 2 Iron, 2 Sulfur Cluster Binding Iron-sulfur Cluster Binding Atrial Cardiac Muscle Cell Development Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Ciliary Pocket Membrane Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Autophagosome Membrane Docking Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cellular Homeostasis Fascia Adherens Preribosome Binding Ventricular Cardiac Muscle Cell Development Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
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