BOLA1 and GLRX5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology)

		BOLA1	GLRX5
Description		bolA family member 1	glutaredoxin 5
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GO Annotations	Cellular Component	Mitochondrion Iron-sulfur Cluster Assembly Complex	Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body Iron-sulfur Cluster Assembly Complex
	Molecular Function	Protein Binding	Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly Cell Redox Homeostasis	Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly Hemopoiesis [2Fe-2S] Cluster Assembly Cell Redox Homeostasis Protein Maturation
Pathways			Mitochondrial iron-sulfur cluster biogenesis
Drugs
Diseases			Sideroblastic anemia, including: Pyridoxine-refractory autosomal recessive sideroblastic anemia (PRARSA); X-linked sideroblastic anemia (XLSA); X-linked sideroblastic anemia with ataxia (ASAT) Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP)
GWAS		Hip circumference adjusted for BMI ( 34021172)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Diisocyanate-induced asthma ( 25918132) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: APP BIRC2 BIRC7 C1orf94 GLRX5 HDX TXNRD3 XIAP ZNF572	4 interacting genes: APP BOLA1 BOLA3 KEAP1
Entrez ID		51027	51218
HPRD ID		13036	12659
Ensembl ID		ENSG00000178096	ENSG00000182512
Uniprot IDs		Q9Y3E2	A0A384MDT9 Q86SX6
PDB IDs		5LCI	2MMZ 2WUL
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of JNK Cascade Copper Ion Homeostasis Peptidase Inhibitor Activity Regulation Of JNK Cascade Protein Serine/threonine Kinase Binding Regulation Of Protein Polyubiquitination Regulation Of Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Cell Redox Homeostasis Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Canonical NF-kappaB Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Natural Killer Cell Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Activity Apoptotic Process Cell Death Positive Regulation Of Protein Modification Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Inflammatory Response Response To CAMP Programmed Cell Death FBXO Family Protein Binding Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Negative Regulation Of Cytokine-mediated Signaling Pathway Inorganic Ion Homeostasis Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Response To Cytokine Stimulus Protein-folding Chaperone Binding Regulation Of Innate Immune Response Positive Regulation Of Protein K48-linked Ubiquitination Regulation Of Cell Cycle Regulation Of Non-canonical NF-kappaB Signal Transduction	Iron-sulfur Cluster Assembly Complex Iron-sulfur Cluster Assembly Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Cell Redox Homeostasis Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Intracellular Iron Ion Homeostasis Intracellular Chemical Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Homeostasis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Chemical Homeostasis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Lipoic Acid Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Homeostatic Process Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity
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