GLRX5

Description		glutaredoxin 5
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body Iron-sulfur Cluster Assembly Complex
	Molecular Function	Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly Hemopoiesis [2Fe-2S] Cluster Assembly Cell Redox Homeostasis Protein Maturation
Pathways		Mitochondrial iron-sulfur cluster biogenesis
Drugs
Diseases		Sideroblastic anemia, including: Pyridoxine-refractory autosomal recessive sideroblastic anemia (PRARSA); X-linked sideroblastic anemia (XLSA); X-linked sideroblastic anemia with ataxia (ASAT) Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Diisocyanate-induced asthma ( 25918132) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: APP BOLA1 BOLA3 KEAP1
Entrez ID		51218
HPRD ID		12659
Ensembl ID		ENSG00000182512
Uniprot IDs		A0A384MDT9 Q86SX6
PDB IDs		2MMZ 2WUL
Enriched GO Terms of Interacting Partners?		Iron-sulfur Cluster Assembly Complex Iron-sulfur Cluster Assembly Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Cell Redox Homeostasis Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Intracellular Iron Ion Homeostasis Intracellular Chemical Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Homeostasis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Chemical Homeostasis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Lipoic Acid Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Homeostatic Process Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity
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