RRP15 and CLN8

Number of citations of the paper that reports this interaction (PubMedID 23142642)
0

Data Source:
BioGRID (two hybrid)

		RRP15	CLN8
Description		ribosomal RNA processing 15 homolog	CLN8 transmembrane ER and ERGIC protein
Image			No pdb structure
GO Annotations	Cellular Component	Preribosome, Large Subunit Precursor	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Presynapse
	Molecular Function		Protein Binding Ceramide Binding
	Biological Process	Maturation Of 5.8S RRNA Maturation Of LSU-rRNA RRNA Processing	Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Apoptotic Process Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Adult Locomotory Behavior Regulation Of Cell Size Lipid Biosynthetic Process Macromolecule Catabolic Process Spinal Cord Motor Neuron Differentiation Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Neuron Apoptotic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Neuron Apoptotic Process Glutamate Reuptake Lipid Homeostasis Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization Retinal Rod Cell Apoptotic Process
Pathways
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Chronic obstructive pulmonary disease ( 30804561) Hip circumference adjusted for BMI ( 34021172)	Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		2 interacting genes: APP CLN8	31 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 FZD7 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC USP40 YIPF6 ZUP1
Entrez ID		51018	2055
HPRD ID		10822	06383
Ensembl ID		ENSG00000067533	ENSG00000182372
Uniprot IDs		Q9Y3B9	Q9UBY8
PDB IDs		8FKP 8FKQ 8FKR 8FKS
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Presynapse Growth Cone Lamellipodium Cognition Adult Locomotory Behavior Regulation Of Neuron Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Regulation Of Response To Calcium Ion Learning Or Memory Amylin Binding Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Learning Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Locomotory Behavior Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Somatic Motor Neuron Differentiation Glutamate Reuptake Retinal Rod Cell Apoptotic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Proteolysis Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Retinal Cell Apoptotic Process Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Membrane Organization Membrane Organization Myelin Sheath Mitochondrial Outer Membrane Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Regulation Of Mitochondrial Membrane Permeability Structural Constituent Of Myelin Sheath Regulation Of Membrane Permeability Central Nervous System Myelination Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Glial Cell Migration
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