PCDH9 and HTR2A

		PCDH9	HTR2A
Description		protocadherin 9	5-hydroxytryptamine receptor 2A
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GO Annotations	Cellular Component	Plasma Membrane Membrane Growth Cone Cell-cell Contact Zone Synaptic Membrane Glutamatergic Synapse	Neurofilament Plasma Membrane Caveola Membrane Axon Dendrite Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Shaft Synapse Postsynaptic Membrane Cell Body Fiber G Protein-coupled Serotonin Receptor Complex Presynapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding	Gq/11-coupled Serotonin Receptor Activity Virus Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Protein Tyrosine Kinase Activator Activity Neurotransmitter Receptor Activity Identical Protein Binding Protein-containing Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Forebrain Development	Temperature Homeostasis Positive Regulation Of Cytokine Production Involved In Immune Response Glycolytic Process Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Memory Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Positive Regulation Of Heat Generation Response To Cocaine Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Sensitization Behavioral Response To Cocaine Positive Regulation Of Inflammatory Response Sensory Perception Of Temperature Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Platelet Aggregation Positive Regulation Of DNA Biosynthetic Process
Pathways			Serotonin receptors G alpha (q) signalling events
Drugs			Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Promazine Cyproheptadine Imipramine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Fenfluramine Lisuride Cisapride Fluphenazine Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupentixol Cyclobenzaprine Mesoridazine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine MMDA Midomafetamine Dimethyltryptamine 4-Bromo-2,5-dimethoxyphenethylamine Acepromazine Molindone Pipotiazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Flibanserin Iloperidone HY10275 APD791 Pimavanserin Epicept NP-1 BL-1020 Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Amisulpride Dotarizine Deramciclane Esmirtazapine Nandrolone decanoate Cinitapride Lurasidone Serotonin Perospirone Amperozide Butriptyline Cannabidiol Brexpiprazole Dosulepin Etoperidone Lorpiprazole Blonanserin Zotepine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Sarpogrelate Eplivanserin Ketanserin Nelotanserin Ritanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil Volinanserin
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Chronotype ( 30696823) Clostridioides difficle infection ( 33841421) Current cigarettes per day in chronic obstructive pulmonary disease ( 29631575) Dental caries ( 23064961) Feeling nervous ( 29500382) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) Gastroesophageal reflux disease ( 34187846) General factor of neuroticism ( 30867560) Insomnia ( 29520036) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Latent naming speed ( 30995994) Major depressive disorder ( 27479909) Male fertility ( 22633400) Metabolite levels ( 23823483) Obesity ( 21552555) Photic sneeze reflex ( 27182965) Postoperative survival time in hepatocellular carcinoma ( 30945673 30945699) Pulmonary function decline ( 22424883) Recalcitrant atopic dermatitis ( 25935106) Refractive error ( 32231278) Response to platinum-based chemotherapy (cisplatin) ( 21844884) Sense of smell ( 26632684) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258)	Cardiac hypertrophy ( 21348951) Femur bone mineral density x serum urate levels interaction ( 34046847) Parkinson disease and lewy body pathology ( 25663231) Serum 25-Hydroxyvitamin D levels ( 29325163) Sjögren's syndrome ( 28076899) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		2 interacting genes: CYSLTR2 MEOX2	19 interacting genes: ANKS1B ARF1 ARF6 DLG1 DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3
Entrez ID		5101	3356
HPRD ID		04661	01638
Ensembl ID		ENSG00000184226	ENSG00000102468
Uniprot IDs		A7E2D9 B7ZM79 Q5VT82 Q9HC56 X5D7N0	A0A7P0PKG8 P28223
PDB IDs		2EE0	6A93 6A94 6WGT 6WH4 6WHA 7RAN 7VOD 7VOE 7WC4 7WC5 7WC6 7WC7 7WC8 7WC9 8JT8 8UWL 8V6U 8ZMG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Serotonin Receptor Complex Artery Smooth Muscle Contraction 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Sensory Perception Of Temperature Stimulus Serotonin Binding Cell Body Fiber Gq/11-coupled Serotonin Receptor Activity Urinary Bladder Smooth Muscle Contraction G Protein-coupled Receptor Activity Nonassociative Learning Serotonin Receptor Signaling Pathway Tonic Smooth Muscle Contraction Positive Regulation Of Heat Generation Sensitization Phospholipase C-activating Serotonin Receptor Signaling Pathway Positive Regulation Of Phospholipid Biosynthetic Process Neurofilament Somite Specification Leukotriene Signaling Pathway Galanin Receptor Activity Cysteinyl Leukotriene Receptor Activity Leukotriene Receptor Activity Positive Regulation Of Platelet Aggregation Serotonin Receptor Activity Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain G Protein-coupled Serotonin Receptor Activity Protein Tyrosine Kinase Activator Activity Vascular Associated Smooth Muscle Contraction Segment Specification Somite Development Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Behavioral Response To Cocaine Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity Positive Regulation Of Homotypic Cell-cell Adhesion G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Positive Regulation Of Glycolytic Process Regulation Of Dopamine Secretion Detection Of Mechanical Stimulus Involved In Sensory Perception Positive Regulation Of Vasoconstriction Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Platelet Aggregation Negative Regulation Of Potassium Ion Transport Vasoconstriction Regulation Of Phospholipid Metabolic Process	GDP Binding Postsynaptic Density Organization G Protein Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTPase Activity Postsynaptic Specialization Organization GTP Binding Nucleotide Binding Heterotrimeric G-protein Complex Maintenance Of Postsynaptic Density Structure Neuron Projection Organization Synapse Positive Regulation Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Platelet Activation Plasma Membrane Protein Localization To Synapse Maintenance Of Postsynaptic Specialization Structure Regulation Of Biological Quality Response To Lipid Synaptic Membrane Glutamatergic Synapse Positive Regulation Of Platelet Aggregation Acetylcholine Receptor Binding G Protein-coupled Receptor Binding Phototransduction, Visible Light Cytosol Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Protein Localization Protein Localization To Cell Junction Response To Ketone Hydrolase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Cytoplasm G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Density Regulation Of Protein Secretion Detection Of Visible Light Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Cellular Response To PH Response To Prostaglandin E Regulation Of Receptor-mediated Endocytosis Entrainment Of Circadian Clock Enzyme Regulator Activity Regulation Of Cytoskeleton Organization
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