PCCB and PCCA

Number of citations of the paper that reports this interaction (PubMedID 11749052)
0

Data Source:
HPRD (two hybrid)

		PCCB	PCCA
Description		propionyl-CoA carboxylase subunit beta	propionyl-CoA carboxylase subunit alpha
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Catalytic Complex	Mitochondrion Mitochondrial Matrix Cytosol Catalytic Complex
	Molecular Function	Nucleotide Binding Propionyl-CoA Carboxylase Activity Protein Binding ATP Binding Ligase Activity	Nucleotide Binding Propionyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Ligase Activity, Forming Carbon-carbon Bonds Enzyme Binding Metal Ion Binding
	Biological Process	Fatty Acid Metabolic Process Fatty Acid Catabolic Process Branched-chain Amino Acid Metabolic Process Short-chain Fatty Acid Catabolic Process	Lipid Metabolic Process Fatty Acid Metabolic Process Branched-chain Amino Acid Metabolic Process Lipid Catabolic Process Short-chain Fatty Acid Catabolic Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism Mitochondrial protein degradation	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism
Drugs		Biotin Valine	Biotin
Diseases		Propionic acidemia	Propionic acidemia
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Autism spectrum disorder or schizophrenia ( 28540026) Coronary artery disease ( 33020668) Fibrinogen ( 20031576 23969696) Fibrinogen levels ( 28107422) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Height ( 20881960 28552196) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Metabolic syndrome ( 31589552) Non-word reading ( 30741946) Schizophrenia ( 25056061 28991256 29483656) Serum alkaline phosphatase levels ( 33339817 33547301) Systolic blood pressure ( 30224653) Total bilirubin levels ( 29403010) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Walking pace ( 33128006)	Chromosomal aberration frequency (chromatid type) in genotoxic compound exposure ( 31586183) Corpus callosum anterior volume ( 31530798) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 23396134 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		8 interacting genes: ACTN3 DSCR9 FBXL17 FXR1 H19 MTDH PCAT1 PCCA	6 interacting genes: ERRFI1 H19 MCC PCCB PJA1 TMEM132D
Entrez ID		5096	5095
HPRD ID		01982	01981
Ensembl ID		ENSG00000114054	ENSG00000175198
Uniprot IDs		P05166	P05165
PDB IDs		7YBU 8XL3 8XL4 8XL5	2CQY 2JKU 7YBU 8XL3 8XL4 8XL5
Enriched GO Terms of Interacting Partners?
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