PCCB

Description		propionyl-CoA carboxylase subunit beta
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Catalytic Complex
	Molecular Function	Nucleotide Binding Propionyl-CoA Carboxylase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Fatty Acid Metabolic Process Fatty Acid Catabolic Process Branched-chain Amino Acid Metabolic Process Short-chain Fatty Acid Catabolic Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism Mitochondrial protein degradation
Drugs		Biotin Valine
Diseases		Propionic acidemia
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Autism spectrum disorder or schizophrenia ( 28540026) Coronary artery disease ( 33020668) Fibrinogen ( 20031576 23969696) Fibrinogen levels ( 28107422) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Height ( 20881960 28552196) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Metabolic syndrome ( 31589552) Non-word reading ( 30741946) Schizophrenia ( 25056061 28991256 29483656) Serum alkaline phosphatase levels ( 33339817 33547301) Systolic blood pressure ( 30224653) Total bilirubin levels ( 29403010) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Walking pace ( 33128006)
Novel Interacting Genes		1 novel interacting genes: EPHB1
Interacting Genes		8 interacting genes: ACTN3 DSCR9 FBXL17 FXR1 H19 MTDH PCAT1 PCCA
Entrez ID		5096
HPRD ID		01982
Ensembl ID		ENSG00000114054
Uniprot IDs		P05166
PDB IDs		7YBU 8XL3 8XL4 8XL5
Enriched GO Terms of Interacting Partners?
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