IL22 and IL22RA2

Number of citations of the paper that reports this interaction (PubMedID 11390453)
0

Data Source:
HPRD (in vitro)

		IL22	IL22RA2
Description		interleukin 22	interleukin 22 receptor subunit alpha 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Cytosol Plasma Membrane
	Molecular Function	Cytokine Activity Protein Binding Interleukin-22 Receptor Binding	Cytokine Receptor Activity Interleukin-22 Binding Interleukin-22 Receptor Activity
	Biological Process	Acute-phase Response Inflammatory Response Signal Transduction Negative Regulation Of Inflammatory Response Response To Glucocorticoid	Cytokine-mediated Signaling Pathway Negative Regulation Of Inflammatory Response Interleukin-22-mediated Signaling Pathway
Pathways		Interleukin-20 family signaling Signaling by ALK fusions and activated point mutants	Interleukin-20 family signaling
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 19122664)	Multiple sclerosis ( 21833088 24076602)
Interacting Genes		5 interacting genes: IL10RB IL22RA1 IL22RA2 S100A6 S100P	1 interacting genes: IL22
Entrez ID		50616	116379
HPRD ID		05621	05973
Ensembl ID		ENSG00000127318	ENSG00000164485
Uniprot IDs		A0A7R8C389 Q9GZX6	Q969J5
PDB IDs		1M4R 1YKB 3DGC 3DLQ 3G9V 3Q1S	3G9V
Enriched GO Terms of Interacting Partners?		Interleukin-22 Receptor Activity Interleukin-22-mediated Signaling Pathway Cytokine Receptor Activity Cytokine-mediated Signaling Pathway Calcium-dependent Protein Binding Interleukin-22 Binding Interleukin-10 Receptor Activity Interferon Receptor Activity Interleukin-28 Receptor Complex Interleukin-20 Binding Negative Regulation Of Inflammatory Response Plasma Membrane Type III Interferon-mediated Signaling Pathway Interleukin-10-mediated Signaling Pathway Negative Regulation Of Defense Response Positive Regulation Of Cellular Respiration Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Transition Metal Ion Binding Regulation Of Inflammatory Response Microvillus Membrane	Nuclear Matrix Organization Cytoskeleton-nuclear Membrane Anchor Activity Nuclear Matrix Anchoring At Nuclear Membrane Interleukin-22 Receptor Binding Meiotic Nuclear Membrane Microtubule Tethering Complex Lamin Binding Maintenance Of Protein Location In Nucleus Nuclear Outer Membrane Maintenance Of Protein Localization In Organelle Acute-phase Response Maintenance Of Protein Location In Cell Sarcomere Maintenance Of Protein Location Acute Inflammatory Response Maintenance Of Location In Cell Maintenance Of Location
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