IL22 and IL22RA1

Number of citations of the paper that reports this interaction (PubMedID 11035029)
0

Data Source:
HPRD (in vivo)

		IL22	IL22RA1
Description		interleukin 22	interleukin 22 receptor subunit alpha 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Protein Binding Interleukin-22 Receptor Binding	Cytokine Receptor Activity Interferon Receptor Activity Protein Binding Interleukin-20 Binding Interleukin-22 Receptor Activity
	Biological Process	Acute-phase Response Inflammatory Response Signal Transduction Negative Regulation Of Inflammatory Response Response To Glucocorticoid	Cytokine-mediated Signaling Pathway Negative Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Interleukin-22-mediated Signaling Pathway
Pathways		Interleukin-20 family signaling Signaling by ALK fusions and activated point mutants	Interleukin-20 family signaling
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 19122664)
Interacting Genes		5 interacting genes: IL10RB IL22RA1 IL22RA2 S100A6 S100P	2 interacting genes: FBXW12 IL22
Entrez ID		50616	58985
HPRD ID		05621	16108
Ensembl ID		ENSG00000127318	ENSG00000142677
Uniprot IDs		A0A7R8C389 Q9GZX6	Q8N6P7
PDB IDs		1M4R 1YKB 3DGC 3DLQ 3G9V 3Q1S	3DGC 3DLQ 6DF3
Enriched GO Terms of Interacting Partners?		Interleukin-22 Receptor Activity Interleukin-22-mediated Signaling Pathway Cytokine Receptor Activity Cytokine-mediated Signaling Pathway Calcium-dependent Protein Binding Interleukin-22 Binding Interleukin-10 Receptor Activity Interferon Receptor Activity Interleukin-28 Receptor Complex Interleukin-20 Binding Negative Regulation Of Inflammatory Response Plasma Membrane Type III Interferon-mediated Signaling Pathway Interleukin-10-mediated Signaling Pathway Negative Regulation Of Defense Response Positive Regulation Of Cellular Respiration Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Transition Metal Ion Binding Regulation Of Inflammatory Response Microvillus Membrane	Interleukin-22 Receptor Binding
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