QDPR

Description		quinoid dihydropteridine reductase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	6,7-dihydropteridine Reductase Activity Electron Transfer Activity Oxidoreductase Activity NADPH Binding NADH Binding
	Biological Process	Amino Acid Metabolic Process L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Pteridine-containing Compound Metabolic Process Dihydrobiopterin Metabolic Process
Pathways		Phenylalanine metabolism
Drugs		NADH 2-(N-morpholino)ethanesulfonic acid
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576)
Interacting Genes		5 interacting genes: ANKRD13A CASP8 KRAS PAH RXFP4
Entrez ID		5860
HPRD ID		02025
Ensembl ID		ENSG00000151552
Uniprot IDs		A0A140VKA9 P09417
PDB IDs		1HDR
Enriched GO Terms of Interacting Partners?		Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development GMP Binding Forebrain Astrocyte Development Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Negative Regulation Of Protein Localization To Endosome Death Effector Domain Binding Response To Isolation Stress Positive Regulation Of Pyroptotic Inflammatory Response Response To Anesthetic Ripoptosome Self Proteolysis Response To Cobalt Ion Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process CD95 Death-inducing Signaling Complex TRAIL-activated Apoptotic Signaling Pathway Mitochondrial Outer Membrane LRR Domain Binding Type I Pneumocyte Differentiation Response To Gravity L-phenylalanine Catabolic Process Ubiquitin-modified Protein Reader Activity Galanin Receptor Activity Positive Regulation Of Feeding Behavior Myoblast Proliferation Positive Regulation Of Macrophage Differentiation Protein-containing Complex Binding Positive Regulation Of Cellular Senescence Tyrosine Metabolic Process Negative Regulation Of Receptor Internalization
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