DELEC1 and TNFSF15

		DELEC1	TNFSF15
Description		deleted in esophageal cancer 1	TNF superfamily member 15
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function		Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation	Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			TNFs bind their physiological receptors
Drugs
Diseases			Crohn's disease
GWAS			Asthma ( 32296059) Asthma (childhood onset) ( 34022066) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 32581322 30500874 23266558 26891255) Inflammatory bowel disease ( 18758464 27569725 23128233) Leprosy ( 25642632 20018961) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28062665 28425483 23000144 30643196) Ulcerative colitis ( 21297633 20848476) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		29 interacting genes: BHLHE41 BMAL1 CIPC CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B EZH2 FBXL15 GSK3B NFIL3 NONO NPAS2 NR1D2 PER1 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E RORB RORC	2 interacting genes: TNFRSF25 TNFRSF6B
Entrez ID		50514	9966
HPRD ID		16068	04956
Ensembl ID		ENSG00000173077	ENSG00000181634
Uniprot IDs			A0A0U5JA19 O95150
PDB IDs			2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?		Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Phosphatase Type 2A Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Circadian Rhythm Protein Kinase CK2 Complex Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process CLOCK-BMAL Transcription Complex E-box Binding Glycogen Metabolic Process Response To Light Stimulus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Polysaccharide Metabolic Process PTW/PP1 Phosphatase Complex Energy Reserve Metabolic Process Regulation Of Metabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Protein Serine/threonine Phosphatase Activity Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Phosphatase Regulator Activity	L-arginine Catabolic Process To L-glutamate Ornithine Aminotransferase Activity L-arginine Catabolic Process To Proline Via Ornithine
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