PCSK6 and SNRPA1

		PCSK6	SNRPA1
Description		proprotein convertase subtilisin/kexin type 6	small nuclear ribonucleoprotein polypeptide A'
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Endomembrane System Membrane Extracellular Matrix	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP Nuclear Body Nuclear Speck Small Nuclear Ribonucleoprotein Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Nerve Growth Factor Binding	RNA Binding Protein Binding U2 SnRNA Binding
	Biological Process	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Plasma Lipoprotein Particle Remodeling	MRNA Splicing, Via Spliceosome MRNA Processing Spermatogenesis RNA Splicing U2-type Prespliceosome Assembly
Pathways		Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	mRNA Splicing - Major Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)	Lung cancer ( 28604730) Relative hand skill in reading disability ( 24068947)
Interacting Genes		7 interacting genes: CACNA1A DYRK1A FLG PCSK5 PMCH RCN3 ZNF441	9 interacting genes: CEBPA FOXP1 IKZF1 NCBP1 PICK1 PTEN SNRPA SNRPB2 ZGPAT
Entrez ID		5046	6627
HPRD ID		01329	04629
Ensembl ID		ENSG00000140479	ENSG00000131876
Uniprot IDs		A2RQD9 H7BXT3 P29122 Q59H04	P09661
PDB IDs			1A9N 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QX9 6Y53 6Y5Q 7A5P 7ABG 7ABI 7EVO 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 9FMD
Enriched GO Terms of Interacting Partners?		Phosphoethanolamine Phosphatase Activity Response To Vitamin B6 Futile Creatine Cycle Phosphoamidase Activity Extracellular Membrane-bounded Organelle Response To Amyloid-beta Cellular Response To Amyloid-beta Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Type 1 Melanin-concentrating Hormone Receptor Binding Negative Regulation Of Synaptic Transmission, Dopaminergic Melanin-concentrating Hormone Activity Neurofilament Cytoskeleton Fast-twitch Skeletal Muscle Fiber Contraction Protein-fructosamine 3-kinase Activity Fructosamine Metabolic Process Protein Deglycation Protein-ribulosamine 3-kinase Activity Fructoselysine Metabolic Process	Spliceosomal SnRNP Complex U1 SnRNA Binding Mononuclear Cell Differentiation Ubiquitin-specific Protease Binding U1 SnRNP Leukocyte Differentiation Protein Domain Specific Binding Negative Regulation Of Macromolecule Metabolic Process Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Myeloid Cell Differentiation Identical Protein Binding Lymphocyte Differentiation Positive Regulation Of RNA Binding Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Neuron Projection Organization Negative Regulation Of Synaptic Vesicle Clustering Dendritic Spine Organization Postsynapse Organization Negative Regulation Of Organ Growth Negative Regulation Of Leukocyte Apoptotic Process DNA-binding Transcription Factor Activity Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of Peptidyl-tyrosine Phosphorylation Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Interleukin-21 Production Derlin-1-VIMP Complex Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process CHOP-C/EBP Complex Response To Lipid Cellular Response To Tumor Necrosis Factor RNA Splicing RNA Cap Binding Complex Ribonucleoprotein Complex Nuclear Cap Binding Complex Negative Regulation Of Developmental Growth Regulation Of Organ Growth Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?