SNRPA1 and NCBP1

Number of citations of the paper that reports this interaction (PubMedID 2148205)
25

Data Source:
HPRD (in vivo)

		SNRPA1	NCBP1
Description		small nuclear ribonucleoprotein polypeptide A'	nuclear cap binding protein subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP Nuclear Body Nuclear Speck Small Nuclear Ribonucleoprotein Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Cap Binding Complex RNA Cap Binding Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding U2 SnRNA Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA Binding Protein Binding Molecular Adaptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Spermatogenesis RNA Splicing U2-type Prespliceosome Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal Complex Assembly Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Cap-dependent Translational Initiation 7-methylguanosine MRNA Capping MRNA Processing RNA Catabolic Process MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translation Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing RNA Metabolic Process MRNA Metabolic Process Positive Regulation Of Cell Growth Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Transport Defense Response To Virus Positive Regulation Of RNA Binding
Pathways		mRNA Splicing - Major Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Relative hand skill in reading disability ( 24068947)	Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		9 interacting genes: CEBPA FOXP1 IKZF1 NCBP1 PICK1 PTEN SNRPA SNRPB2 ZGPAT	19 interacting genes: BNIP1 BNIP2 BNIP3 DSCR9 EIF4G1 EIF4G2 HNRNPF HNRNPH1 LINC01554 NCBP2 PSTPIP1 PTEN RNF10 RNF20 RNF40 RPS6KB1 SNRPA1 STAU1 ZDHHC17
Entrez ID		6627	4686
HPRD ID		04629	02717
Ensembl ID		ENSG00000131876	ENSG00000136937
Uniprot IDs		P09661	Q09161
PDB IDs		1A9N 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QX9 6Y53 6Y5Q 7A5P 7ABG 7ABI 7EVO 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 9FMD	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY 5OO6 5OOB 6D0Y 7ABG 8BY6 8PMP 8PNT 8SRR 8SUY
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Complex U1 SnRNA Binding Mononuclear Cell Differentiation Ubiquitin-specific Protease Binding U1 SnRNP Leukocyte Differentiation Protein Domain Specific Binding Negative Regulation Of Macromolecule Metabolic Process Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Myeloid Cell Differentiation Identical Protein Binding Lymphocyte Differentiation Positive Regulation Of RNA Binding Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Neuron Projection Organization Negative Regulation Of Synaptic Vesicle Clustering Dendritic Spine Organization Postsynapse Organization Negative Regulation Of Organ Growth Negative Regulation Of Leukocyte Apoptotic Process DNA-binding Transcription Factor Activity Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of Peptidyl-tyrosine Phosphorylation Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Interleukin-21 Production Derlin-1-VIMP Complex Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process CHOP-C/EBP Complex Response To Lipid Cellular Response To Tumor Necrosis Factor RNA Splicing RNA Cap Binding Complex Ribonucleoprotein Complex Nuclear Cap Binding Complex Negative Regulation Of Developmental Growth Regulation Of Organ Growth Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission	Response To Oxygen-glucose Deprivation Regulation Of Translational Initiation HULC Complex Cap-dependent Translational Initiation Nuclear Envelope Multicellular Organismal Response To Stress Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Macromolecule Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Cell Cycle Response To Nutrient Levels Macromolecule Metabolic Process Negative Regulation Of Autophagy Regulation Of Mitotic Cell Cycle Translation Factor Activity, RNA Binding MRNA Binding Ubiquitin-specific Protease Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Cell Death Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Regulation Of Autophagy Protein Metabolic Process Mitochondrion Autophagosome Adaptor Activity Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Fear Response Behavioral Fear Response Behavioral Defense Response RNA Splicing Negative Regulation Of Synaptic Vesicle Clustering Proteolysis Involved In Protein Catabolic Process Cytoplasmic Side Of Nuclear Pore Perforant Pathway To Dendrate Granule Cell Synapse Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Spliceosomal Complex Regulation Of Translation RNA Binding Translation Initiation Factor Activity MRNA Processing Mitochondrial Outer Membrane Apoptotic Process In Response To Mitochondrial Fragmentation Cellular Response To Oxidative Stress Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
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