TMEM74 and SPCS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM74	SPCS1
Description		transmembrane protein 74	signal peptidase complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Plasma Membrane Membrane Cytoplasmic Vesicle	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Binding	Protein Binding
	Biological Process	Autophagy Macroautophagy General Adaptation Syndrome, Behavioral Process	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER
Pathways			SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs
Diseases
GWAS		Male-pattern baldness ( 27182965)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 23974872 25056061 28991256 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: AQP6 FATE1 LIME1 LMNA MS4A13 SPCS1 TMEM42	9 interacting genes: AQP2 FIS1 FXYD6-FXYD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2
Entrez ID		157753	28972
HPRD ID		08702	07155
Ensembl ID		ENSG00000164841	ENSG00000114902
Uniprot IDs		Q96NL1	A0A5F9YFS9 Q9Y6A9
PDB IDs			7P2P 7P2Q
Enriched GO Terms of Interacting Partners?		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Signal Peptidase Complex B Cell Receptor Complex Negative Regulation Of Mitochondrial Calcium Ion Concentration Monoatomic Anion Channel Activity Renal Water Transport Negative Regulation Of Mesenchymal Cell Proliferation Virion Assembly Ammonium Channel Activity Signal Peptide Processing Ammonium Transmembrane Transport Ventricular Cardiac Muscle Cell Development	Mitochondrial Fission Lumenal Side Of Membrane Polyol Transmembrane Transport Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Metanephric Collecting Duct Development Cellular Response To Water Deprivation Organic Hydroxy Compound Transport Glycerol Transmembrane Transporter Activity Response To Mercury Ion Membrane Serotonin Uptake Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transport Norepinephrine Uptake Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Across Blood-brain Barrier Spermidine Transport Toxin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Epinephrine Transport Choline Transmembrane Transporter Activity Spermidine Transmembrane Transport Putrescine Transport Norepinephrine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Amine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Polyamine Transmembrane Transport Thiamine Transmembrane Transport Histamine Transport L-arginine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Response To Flavonoid Response To Fluoride Negative Regulation Of Fatty Acid Transport Response To Hypobaric Hypoxia Cellular Response To Peptide Golgi Trans Cisterna Golgi Medial Cisterna Mitochondrial Membrane Fission
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