P2RY2 and ITGB5

Number of citations of the paper that reports this interaction (PMID 11331301)
31

Data Source:
HPRD (in vitro, in vivo)

		P2RY2	ITGB5
Gene Name		purinergic receptor P2Y, G-protein coupled, 2	integrin, beta 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Focal Adhesion Cell Surface Cell Leading Edge Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity G-protein Coupled Purinergic Nucleotide Receptor Activity	Receptor Activity Integrin Binding Protein Binding
	Biological Process	Cellular Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Vasodilation Positive Regulation Of Mucus Secretion	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Muscle Contraction Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Extracellular Matrix Organization Endodermal Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Stress Fiber Assembly Epithelial Cell-cell Adhesion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Nucleotide-like (purinergic) receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding P2Y receptors	Elastic fibre formation Smooth Muscle Contraction Non-integrin membrane-ECM interactions Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS		Body mass index (asthmatics) ( 23517042) Insomnia (caffeine-induced) ( 22754043)
Protein-Protein Interactions		7 interactors: APP CD47 ITGAV ITGB3 ITGB5 KDR SRC	34 interactors: ANXA5 CYR61 DAB1 DAB2 DOK1 EHMT2 EPS8 EWSR1 FHL2 FLNA GNB2L1 ITGA5 ITGAV ITGB3BP KRT40 KRTAP10-8 KRTAP10-9 LTBP1 LTBP3 MTUS2 MYO10 NOTCH2NL NUMB P2RY2 PAK4 PALLD PIAS2 PPARD PTK2 SNTA1 SRSF9 TLN1 TNS2 ZBTB17
Entrez ID		5029	3693
HPRD ID		02499	00949
Ensembl ID		ENSG00000175591	ENSG00000082781
Uniprot IDs		P41231	L7RT22 P18084
PDB IDs		1Z8E
Enriched GO Terms of Interacting Partners?		Integrin-mediated Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Immune System Process Cell Adhesion Locomotion Regulation Of Body Fluid Levels Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Substrate Adhesion-dependent Cell Spreading Wound Healing Cell-substrate Adhesion Leukocyte Migration Movement Of Cell Or Subcellular Component Response To Wounding Cell Surface Receptor Signaling Pathway Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Positive Regulation Of Locomotion Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Cell Adhesion Axon Guidance Negative Regulation Of Lipoprotein Metabolic Process Formation Of Primary Germ Layer Regulation Of Lipoprotein Metabolic Process Stress Fiber Assembly Anatomical Structure Morphogenesis Regulation Of Epithelial Cell Migration Single Organismal Cell-cell Adhesion Axonogenesis Cell Growth Negative Regulation Of Macrophage Derived Foam Cell Differentiation Viral Process Regulation Of Receptor Biosynthetic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell-matrix Adhesion Regulation Of Cell Migration Negative Regulation Of Lipid Storage Negative Chemotaxis Chemotaxis Regulation Of Cell Adhesion	Signaling Cell Communication Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Locomotion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Cell Migration Wound Healing Cell Development Regulation Of Cell Motility Movement Of Cell Or Subcellular Component Regulation Of Locomotion Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Positive Regulation Of Protein Phosphorylation Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Cell Migration Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Chemotaxis Positive Regulation Of Phosphorylation Axon Guidance Multicellular Organismal Development Regulation Of Cell Adhesion Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Blood Coagulation Negative Regulation Of Programmed Cell Death Hemostasis Developmental Process Anatomical Structure Development Apoptotic Process Positive Regulation Of Protein Kinase Activity Programmed Cell Death Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Cell Morphogenesis
Tagcloud ?		10d a2a adenosine adora1 adora2a adora3 b4 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
Tagcloud (Difference) ?		10d a2a adenosine adora1 adora2a adora3 b4 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
Tagcloud (Intersection) ?