P2RY2

Description		purinergic receptor P2Y2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding A1 Adenosine Receptor Binding Signaling Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity G Protein-coupled UTP Receptor Activity
	Biological Process	Intracellular Monoatomic Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Mucus Secretion Cellular Response To ATP Blood Vessel Diameter Maintenance
Pathways		G alpha (q) signalling events P2Y receptors Surfactant metabolism High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Promethazine Suramin Denufosol INS 316
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Body mass index in asthmatics ( 23517042) Dentures ( 31235808) Glucose homeostasis traits ( 25524916) Insomnia (caffeine-induced) ( 22754043) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		7 interacting genes: APP CD47 ITGAV ITGB3 ITGB5 KDR SRC
Entrez ID		5029
HPRD ID		02499
Ensembl ID		ENSG00000175591
Uniprot IDs		P41231
PDB IDs
Enriched GO Terms of Interacting Partners?		Integrin Binding Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Wound Healing, Spreading Of Epidermal Cells Regulation Of Endocytosis Symbiont Entry Into Host Cell Cell Adhesion Cell Migration Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Regulation Of Cell Migration Cell-substrate Adhesion Biological Process Involved In Interaction With Host Cell Surface Receptor Signaling Pathway Regulation Of Cell Motility Heterotypic Cell-cell Adhesion Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Adhesion Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Positive Regulation Of ERK1 And ERK2 Cascade Receptor Complex Regulation Of Vesicle-mediated Transport Substrate Adhesion-dependent Cell Spreading Alphav-beta3 Integrin-IGF-1-IGF1R Complex Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Coreceptor Activity Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Fibrinogen Binding Angiogenesis Response To Interleukin-1 Response To Growth Factor Virus Receptor Activity Signaling Receptor Activator Activity Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis External Side Of Plasma Membrane Positive Regulation Of Mononuclear Cell Migration Ruffle Membrane
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