NBPF19 and HHEX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NBPF19	HHEX
Description		NBPF member 19	hematopoietically expressed homeobox
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromatin Nucleus Cytoplasm Nuclear Body Protein-DNA Complex
	Molecular Function		Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Eukaryotic Initiation Factor 4E Binding DNA Binding, Bending TBP-class Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Translation Regulator Activity DNA-binding Transcription Factor Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Regulation Of MRNA Export From Nucleus Negative Regulation Of Transcription By Competitive Promoter Binding Wnt Signaling Pathway Negative Regulation Of Angiogenesis Cell Differentiation Positive Regulation Of Wnt Signaling Pathway B Cell Differentiation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Proliferation DNA Conformation Change Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cytoplasmic Translational Initiation
Pathways			Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases			Type II diabetes mellitus
GWAS		Serum uric acid levels ( 30993211)	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 31619474) Birth weight ( 31043758 27680694) Body mass index ( 28892062) Circulating leptin levels or type 2 diabetes ( 32341051) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hemoglobin A1c levels ( 29403010) Inflammatory bowel disease ( 28067908) Insulin disposition index ( 24699409) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 29785010) Multiple sclerosis ( 24076602 21833088 31604244) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Type 2 diabetes ( 32499647 30054458 30297969 30718926 29358691 17293876 28869590 26818947 24509480 23945395 22885922 22693455 20862305 20581827 19401414 18372903 17463249 17463248 17463246)
Interacting Genes		229 interacting genes: ADAM12 ADAMTSL4 AGXT ALDH16A1 ALPP ANKS1A AQP1 ATG9A ATP5F1D BCAM BMP7 BRME1 CARHSP1 CATSPER1 CCER1 CD164 CELF5 CERK CHCHD3 CHIC2 CHRD CHRNG CNNM3 COL8A1 CREB5 CRH CRY2 CST2 CST9L CTNNBIP1 CTSZ CXCL16 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGKQ DHRS1 DMRT3 DOCK2 DRD5 EMC7 F10 FADS2 FAM221A FAM90A1 FBXW5 FRS3 FTHL17 FZD10 GARIN6 GLP1R GLYAT GNE GSTP1 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSPA12B ICAM4 IGSF8 IL10 INO80B INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KLHL38 KLK8 KPRP KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LMNTD2 LNX1 LRFN4 LYVE1 MACO1 MAPKBP1 MELTF MOS MRGBP MRPL40 MTA1 MXD3 MXI1 MYO15B MYPOP NECTIN2 NECTIN3 NEDD9 NMU NPDC1 NR1D2 NTM NTN4 NUFIP2 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCSK5 PGAP6 PHLDA1 PIGS PLEKHN1 PRF1 PRR19 PRR35 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAB3IL1 RAMP3 RASD1 RECK RNF111 RPS19BP1 RTN4RL1 SCNM1 SEMA3B SEMA4C SHFL SLC22A5 SLC23A1 SLC43A2 SLC5A5 SLC68A1 SLC6A20 SMCP SPATA24 SPATA8 SPG7 SPPL2C SPRY1 STAC STK16 TAPBPL TCAF1 THAP7 TLE5 TMEFF2 TMEM150A TMIE TNIP3 TNS2 TRAPPC14 TRIM42 TROAP TSPAN4 TTPA UTP23 UXT VASN WDR25 ZDHHC1 ZFTRAF1 ZNF124 ZNF319 ZNF330 ZNF408 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF786 ZNF837	41 interacting genes: ABI1 ABI2 APOBEC3C CYSRT1 EFEMP2 GATA2 GATA6 JUN KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP19-1 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 MDFI NBPF19 NOTCH2NLA PFDN5 PML PSMA3 PSTPIP1 RBMY1F RBMY1J SOX10 SOX8 TLE1 TLE5 TP53BP2 TRMT6
Entrez ID		101060226	3087
HPRD ID			06829
Ensembl ID		ENSG00000271383	ENSG00000152804
Uniprot IDs		A0A087WUL8	Q03014
PDB IDs			2E1O
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Keratinization Epidermis Development Hair Cycle Tissue Development Nitric Oxide Transport Carbon Dioxide Transport	Intermediate Filament Keratin Filament Identical Protein Binding Negative Regulation Of Wnt Signaling Pathway Cytosol Negative Regulation Of RNA Biosynthetic Process SH3 Domain Binding Actin-based Cell Projection Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Enteric Nervous System Development SCAR Complex Anatomical Structure Morphogenesis Keratinization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Filopodium Tip
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