CLDN11 and TNFSF14

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CLDN11	TNFSF14
Name		claudin 11	TNF superfamily member 14
Structure		No pdb structure
GO Annotations	Cellular Component	Lipid Droplet Neurofilament Plasma Membrane Bicellular Tight Junction Membrane Cell Junction Axon Basal Part Of Cell Tight Junction Anchoring Junction	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Cell Adhesion Spermatogenesis Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly Tight Junction Assembly	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Chemotaxis Positive Regulation Of T Cell Chemotaxis Signaling T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Fusion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Tight junction interactions	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
GWAS		Blood glucose levels ( 31928498 ) Monocyte chemoattractant protein-1 (red blood cell fatty acid level interaction) ( 28820441 ) Prostate cancer ( 21743467 )	Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte count ( 29403010 ) Monocyte percentage of white cells ( 27863252 ) Multiple sclerosis ( 21833088 24076602 31604244 )
Novel Interactors		None recorded	3 novel interactors: S1PR4 SLC38A3 TCF3
Interacting Genes		12 interacting genes: AMIGO1 C16orf54 FNDC9 KLRC1 SHISA3 SMIM3 SPINT1 TMEM80 TNFSF14 TSPAN3 TSPAN4 ZP3	22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2
Entrez ID		5010	8740
HPRD ID		03207	05157
Ensembl ID		ENSG00000013297	ENSG00000125735
Uniprot IDs		O75508	O43557
PDB IDs		Not available	4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU 7MSG
GO Terms Enriched among Interactors		Membrane	Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Membrane Regulation Of Apoptotic Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Cytokine Activity Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules