FBXL5 and CITED2

Number of citations of the paper that reports this interaction (PubMedID 25956243)
0

Data Source:
BioGRID (two hybrid, pull down, protein complementation assay)

		FBXL5	CITED2
Description		F-box and leucine rich repeat protein 5	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Histone Acetyltransferase Binding SMAD Binding LBD Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Molecular Function Activator Activity
	Biological Process	Intracellular Iron Ion Homeostasis Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Monoatomic Cation Homeostasis Multicellular Organismal-level Iron Ion Homeostasis Inorganic Ion Homeostasis	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Vasculogenesis Response To Hypoxia In Utero Embryonic Development Trophectodermal Cell Differentiation Neural Tube Formation Neural Tube Closure Liver Development Embryonic Placenta Development Vasculature Development Heart Looping Lens Morphogenesis In Camera-type Eye Hematopoietic Progenitor Cell Differentiation Leukocyte Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Regulation Of Animal Organ Formation Endocardial Cushion Development Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Central Nervous System Development Peripheral Nervous System Development Heart Development Sex Determination Cell Population Proliferation Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cranial Nerve Morphogenesis Positive Regulation Of Cell-cell Adhesion Cell Differentiation Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Granulocyte Differentiation Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Skeletal Muscle Cell Differentiation Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Spleen Development Thymus Development Embryonic Camera-type Eye Morphogenesis Erythrocyte Development Uterus Development Embryonic Process Involved In Female Pregnancy Bone Morphogenesis Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Heart Development Determination Of Heart Left/right Asymmetry Left/right Axis Specification Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Senescence Positive Regulation Of Male Gonad Development
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation	Regulation of gene expression by Hypoxia-inducible Factor TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708) Red blood cell count ( 32888494)	Alanine aminotransferase levels ( 33547301) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood trace element (Se levels) ( 23720494) Caudate volume in trauma-exposed individuals ( 29187748) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 32203549 28334899) IgA levels ( 28628107) Mean corpuscular hemoglobin ( 28453575 19862010 28017375 20139978 23263863) Mean corpuscular volume ( 19862010 28017375 32888494 20139978 23263863 28453575) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517) Systolic blood pressure ( 30224653) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Triglyceride levels ( 32203549) Triglycerides ( 25961943) Urate levels in lean individuals ( 25811787)
Interacting Genes		10 interacting genes: CITED2 CSNK2B DCTN1 EP300 LINC00839 NABP2 ORC4 PLK1 SKP1 SNCA	11 interacting genes: CREBBP EP300 FBXL5 HIF1A LHX2 LHX3 MAPK1 TBP TFAP2A TFAP2B TFAP2C
Entrez ID		26234	10370
HPRD ID		05739	04245
Ensembl ID		ENSG00000118564	ENSG00000164442
Uniprot IDs		Q9UKA1	A0A0A0MTM3 D9ZGF1 Q99967
PDB IDs		3U9J 3U9M 3V5X 3V5Y 3V5Z 6VCD	1P4Q 1R8U 7LVS 7QGS
Enriched GO Terms of Interacting Partners?		Tau Protein Binding Protein Domain Specific Binding Protein Destabilization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Membrane Disassembly Nuclear Membrane Disassembly PcG Protein Complex Regulation Of Microtubule Cytoskeleton Organization Molecular Function Activator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cytosol Regulation Of Microtubule-based Process Establishment Of Spindle Localization Establishment Of Spindle Orientation Regulation Of Mitotic Spindle Organization Nuclear Membrane Organization Establishment Of Mitotic Spindle Localization Microtubule Binding Establishment Of Organelle Localization Spindle Localization Regulation Of Organelle Organization Establishment Of Mitotic Spindle Orientation Protein Localization To Chromatin Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Mitotic G2/M Transition Checkpoint Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission C-rich Strand Telomeric DNA Binding Response To Estrogen Regulation Of Microtubule Polymerization Protein-containing Complex Myeloid Cell Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleus Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Histone H2B Acetyltransferase Activity	Chromatin Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Coactivator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Anatomical Structure Formation Involved In Morphogenesis DNA Binding Animal Organ Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Histone H3K27 Acetyltransferase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity Regulation Of Primary Metabolic Process N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Chromatin Binding Regulation Of Metabolic Process Animal Organ Morphogenesis P53 Binding Transcription Regulator Complex Nucleus Cerebral Cortex Development Regulation Of Gene Expression DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process N-terminal Protein Amino Acid Acetylation Transcription By RNA Polymerase II Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Mammary Gland Epithelial Cell Proliferation Regulation Of Ossification Negative Regulation Of DNA-templated Transcription
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