NR4A2 and FAP

		NR4A2	FAP
Description		nuclear receptor subfamily 4 group A member 2	fibroblast activation protein alpha
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Protein-containing Complex	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Membrane Lamellipodium Lamellipodium Membrane Ruffle Membrane Cell Projection Apical Part Of Cell Basal Part Of Cell Anchoring Junction Peptidase Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Nuclear Glucocorticoid Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Neuron Migration Response To Amphetamine DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Adult Locomotory Behavior Post-embryonic Development Gene Expression Regulation Of Gene Expression Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Differentiation Habenula Development Intracellular Receptor Signaling Pathway Cellular Response To Oxidative Stress Regulation Of Dopamine Metabolic Process Dopamine Biosynthetic Process Dopamine Metabolic Process Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Apoptotic Process General Adaptation Syndrome Canonical Wnt Signaling Pathway Cellular Response To Corticotropin-releasing Hormone Stimulus Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Apoptotic Signaling Pathway	Angiogenesis Proteolysis Apoptotic Process Cell Adhesion Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Endothelial Cell Migration Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Regulation Of Fibrinolysis Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Melanocyte Proliferation Positive Regulation Of Execution Phase Of Apoptosis Melanocyte Apoptotic Process Negative Regulation Of Extracellular Matrix Organization
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs			Sibrotuzumab
Diseases		Parkinson's disease (PD)
GWAS		Age at voice drop ( 27182965) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Chronic obstructive pulmonary disease ( 30804561) Depression ( 29700475) HDL cholesterol levels ( 32109663) Leisure-time exercise behaviour ( 30102679) Leisure-time exercise behaviour (age-stratified) ( 30102679) Lung function (FEV1/FVC) ( 30061609) Menarche (age at onset) ( 21102462 25231870) Response to statin therapy ( 20339536) Schizophrenia ( 33169155) Sociability score ( 34054130) Worry too long after an embarrassing experience ( 34054130)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Inflammatory skin disease ( 25574825) Medication use (thyroid preparations) ( 31015401) Regular attendance at a pub or social club ( 29970889) Systemic lupus erythematosus ( 28714469 33272962)
Interacting Genes		16 interacting genes: BAZ1B CDKN1C CDKN2D COPS5 DSCR9 MAPK1 ODAD2 PIAS4 PPARG RPS6KA1 RXRA RXRB SMARCA2 SMARCA4 TCEAL5 VHL	2 interacting genes: DPP4 PLAUR
Entrez ID		4929	2191
HPRD ID		03493	02674
Ensembl ID		ENSG00000153234	ENSG00000078098
Uniprot IDs		F1D8N6 F1DAL2 P43354 Q53EL4	B4DLR2 Q12884
PDB IDs		1OVL 5Y41 5YD6 6DDA 6L6L 6L6Q 7WNH 8CYO	1Z68 6Y0F 9DVQ 9DVR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Domain Binding Chromatin Positive Regulation Of Lipoprotein Transport Nucleosome Array Spacer Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Signal Transduction MRNA Transcription By RNA Polymerase II Transcription Coregulator Binding Positive Regulation Of Vitamin D Receptor Signaling Pathway Nuclear Receptor Activity LBD Domain Binding Retinoic Acid-responsive Element Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II MRNA Transcription Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Vitamin D Receptor Signaling Pathway BBAF Complex System Development Peroxisome Proliferator Activated Receptor Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction NpBAF Complex GBAF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Chromosome Organization NBAF Complex Positive Regulation Of Double-strand Break Repair Transcription Cis-regulatory Region Binding Nuclear Receptor-mediated Signaling Pathway Response To Retinoic Acid Monocyte Differentiation Regulation Of Cell Population Proliferation Nucleoplasm Positive Regulation Of DNA Metabolic Process	Multicellular Organismal Response To Stress Glucagon Processing General Adaptation Syndrome Urokinase Plasminogen Activator Receptor Activity Intercellular Canaliculus Positive Regulation Of Cell-cell Adhesion Adhesion Of Symbiont To Host Signaling Receptor Binding Locomotion Negative Regulation Of Extracellular Matrix Disassembly Locomotory Behavior Anchoring Junction Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Response To Hypoxia Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Neutrophil Migration Regulation Of Cell-cell Adhesion Mediated By Integrin Response To Oxygen Levels Negative Regulation Of Neutrophil Chemotaxis Dipeptidyl-peptidase Activity Response To Decreased Oxygen Levels Psychomotor Behavior Virion Attachment To Host Cell Chemotaxis Endocytosis Involved In Viral Entry Into Host Cell Midbrain Dopaminergic Neuron Differentiation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Habenula Development Nuclear Glucocorticoid Receptor Binding Cellular Response To Corticotropin-releasing Hormone Stimulus Dopamine Biosynthetic Process Serine-type Endopeptidase Complex Protein Complex Involved In Cell-matrix Adhesion Urokinase Plasminogen Activator Signaling Pathway Piccolo Histone Acetyltransferase Complex Locomotory Exploration Behavior Focal Adhesion Nuclear Retinoid X Receptor Binding Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Catecholamine Biosynthetic Process Positive Regulation Of Homotypic Cell-cell Adhesion Extrinsic Component Of Membrane Regulation Of Dopamine Metabolic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Leukocyte Chemotaxis
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