NR4A2 and CHST13

Data Source: HiPPIP (Novel)

		NR4A2	CHST13
Name		nuclear receptor subfamily 4 group A member 2	carbohydrate sulfotransferase 13
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Protein-containing Complex	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Nuclear Glucocorticoid Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Dermatan 4-sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Chondroitin 4-sulfotransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Neuron Migration Response To Amphetamine DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Adult Locomotory Behavior Post-embryonic Development Gene Expression Regulation Of Gene Expression Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Differentiation Habenula Development Intracellular Receptor Signaling Pathway Cellular Response To Oxidative Stress Regulation Of Dopamine Metabolic Process Dopamine Biosynthetic Process Dopamine Metabolic Process Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Apoptotic Process General Adaptation Syndrome Canonical Wnt Signaling Pathway Cellular Response To Corticotropin-releasing Hormone Stimulus Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Apoptotic Signaling Pathway	Carbohydrate Biosynthetic Process Proteoglycan Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	CS-GAG biosynthesis
Diseases		Parkinson's disease (PD)	None
GWAS		Age at voice drop ( 27182965 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Anxiety ( 33859377 ) Chronic obstructive pulmonary disease ( 30804561 ) Depression ( 29700475 ) HDL cholesterol levels ( 32109663 ) Leisure-time exercise behaviour ( 30102679 ) Leisure-time exercise behaviour (age-stratified) ( 30102679 ) Lung function (FEV1/FVC) ( 30061609 ) Menarche (age at onset) ( 21102462 25231870 ) Response to statin therapy ( 20339536 ) Schizophrenia ( 33169155 ) Sociability score ( 34054130 ) Worry too long after an embarrassing experience ( 34054130 )	No GWAS studies recorded
Novel Interactors		3 novel interactors: CHST13 FAP SMPD4	1 novel interactors: NR4A2
Interacting Genes		16 interacting genes: BAZ1B CDKN1C CDKN2D COPS5 DSCR9 MAPK1 ODAD2 PIAS4 PPARG RPS6KA1 RXRA RXRB SMARCA2 SMARCA4 TCEAL5 VHL	1 interacting genes: C3orf52
Entrez ID		4929	166012
HPRD ID		03493	13057
Ensembl ID		ENSG00000153234	ENSG00000180767
Uniprot IDs		F1D8N6 F1DAL2 P43354 Q53EL4	Q8NET6
PDB IDs		1OVL 5Y41 5YD6 6DDA 6L6L 6L6Q 7WNH 8CYO	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Domain Binding Chromatin Positive Regulation Of Lipoprotein Transport Nucleosome Array Spacer Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Signal Transduction MRNA Transcription By RNA Polymerase II Transcription Coregulator Binding Positive Regulation Of Vitamin D Receptor Signaling Pathway Nuclear Receptor Activity LBD Domain Binding Retinoic Acid-responsive Element Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II MRNA Transcription Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Vitamin D Receptor Signaling Pathway BBAF Complex System Development Peroxisome Proliferator Activated Receptor Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction NpBAF Complex GBAF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Chromosome Organization NBAF Complex Positive Regulation Of Double-strand Break Repair Transcription Cis-regulatory Region Binding Nuclear Receptor-mediated Signaling Pathway Response To Retinoic Acid Monocyte Differentiation Regulation Of Cell Population Proliferation Nucleoplasm Positive Regulation Of DNA Metabolic Process	General Adaptation Syndrome Habenula Development Cellular Response To Corticotropin-releasing Hormone Stimulus Midbrain Dopaminergic Neuron Differentiation Nuclear Retinoid X Receptor Binding Regulation Of Dopamine Metabolic Process Amine Biosynthetic Process Central Nervous System Projection Neuron Axonogenesis Catecholamine Biosynthetic Process Response To Amphetamine Nuclear Glucocorticoid Receptor Binding Regulation Of Respiratory Gaseous Exchange Biogenic Amine Biosynthetic Process Dopamine Biosynthetic Process Dopaminergic Neuron Differentiation Neuron Maturation Dopamine Metabolic Process Central Nervous System Neuron Axonogenesis Catecholamine Metabolic Process Response To Amine Nuclear Receptor Activity