NUCB2 and NFRKB

		NUCB2	NFRKB
Description		nucleobindin 2	nuclear factor related to kappaB binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Extracellular Exosome	Nucleus Nucleoplasm Ino80 Complex
	Molecular Function	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Metal Ion Binding	Protease Binding DNA Binding Protein Binding
	Biological Process	Small GTPase-mediated Signal Transduction	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Embryonic Development Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways			UCH proteinases DNA Damage Recognition in GG-NER
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Body mass index ( 26426971) Height ( 20881960) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28739976) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Youthful appearance (self-reported) ( 32339537)	High light scatter reticulocyte count ( 32888494) Night sleep phenotypes ( 27126917) Reticulocyte count ( 32888494)
Interacting Genes		12 interacting genes: ARL13B ASPH FFAR2 GADD45A GNAI3 GNAS NDN NR1I2 SLC7A1 SMARCD1 STAR XPO1	3 interacting genes: EPHB3 NFKB1 TRDMT1
Entrez ID		4925	4798
HPRD ID		09726	01240
Ensembl ID		ENSG00000070081	ENSG00000170322
Uniprot IDs		P80303 Q2L696	Q6P4R8
PDB IDs			3U21 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Regulation Of Protein Transport Heterotrimeric G-protein Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Lipid Cellular Response To Fatty Acid Regulation Of Establishment Of Protein Localization Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Multicellular Organismal Process Peptidyl-aspartic Acid 3-dioxygenase Activity Promoter-specific Chromatin Binding Mu-type Opioid Receptor Binding Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Response To Fatty Acid Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Lysine Transport L-histidine Import Across Plasma Membrane Cellular Response To Triglyceride
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