FZD2

Gene Name		frizzled class receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	G-protein Coupled Receptor Activity Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity
	Biological Process	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Sensory Perception Of Smell Neuron Differentiation Positive Regulation Of CGMP Metabolic Process Epithelial Cell Differentiation Non-canonical Wnt Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hard Palate Development Canonical Wnt Signaling Pathway Inner Ear Receptor Cell Development Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: DLG4 ROR2
Entrez ID		2535
HPRD ID		02813
Ensembl ID
Uniprot IDs		Q14332 Q86UZ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway, Calcium Modulating Pathway Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Maintenance Of Apical/basal Cell Polarity Embryonic Genitalia Morphogenesis Receptor Localization To Synapse Negative Regulation Of Receptor Internalization Locomotory Exploration Behavior Dendritic Spine Morphogenesis Maintenance Of Cell Polarity Synaptic Vesicle Maturation Vocalization Behavior Dendritic Spine Development Protein Localization To Synapse Negative Regulation Of Receptor-mediated Endocytosis Genitalia Morphogenesis Dendritic Spine Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Cartilage Condensation Cortical Actin Cytoskeleton Organization Exploration Behavior Postsynaptic Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization Non-canonical Wnt Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Golgi To Plasma Membrane Transport Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Social Behavior Positive Regulation Of Membrane Potential Negative Regulation Of Endocytosis Receptor Clustering Regulation Of Neuronal Synaptic Plasticity Nucleotide Phosphorylation Genitalia Development Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Phosphorylation Neuromuscular Process Controlling Balance Synapse Assembly Dendrite Morphogenesis Somitogenesis JNK Cascade Post-Golgi Vesicle-mediated Transport Somite Development Inner Ear Morphogenesis
Tagcloud ?		acted analyzing arhgef6 bioinformatic constructed crc dataset david degs disturbed downloaded gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a