ZP2 and ZPBP

Number of citations of the paper that reports this interaction (PubMedID 10924747)
0

Data Source:
HPRD (in vitro)

		ZP2	ZPBP
Description		zona pellucida glycoprotein 2	zona pellucida binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Multivesicular Body Endoplasmic Reticulum Plasma Membrane Membrane Extracellular Matrix Egg Coat	Acrosomal Vesicle Acrosomal Membrane Zona Pellucida Receptor Complex Extracellular Region Nucleus Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Coreceptor Activity Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding
	Biological Process	Single Fertilization Binding Of Sperm To Zona Pellucida Regulation Of Acrosome Reaction Prevention Of Polyspermy	Acrosome Assembly Binding Of Sperm To Zona Pellucida
Pathways		Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		Pelvic organ prolapse ( 26545240)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463 28067908) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Metabolite levels ( 23823483) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		2 interacting genes: ACR ZPBP	3 interacting genes: CALU ERRFI1 ZP2
Entrez ID		7783	11055
HPRD ID		01689	18364
Ensembl ID		ENSG00000103310	ENSG00000042813
Uniprot IDs		Q05996	Q9BS86
PDB IDs		8RKE 8RKF
Enriched GO Terms of Interacting Partners?		Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Acrosomal Vesicle Cell Recognition Acrosome Matrix Dispersal Amidase Activity Acrosomal Matrix Fucose Binding Zona Pellucida Receptor Complex Penetration Of Zona Pellucida Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Acrosome Reaction Golgi-associated Vesicle Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity D-mannose Binding Acrosomal Membrane Acrosome Assembly Copper Ion Binding Reproductive Process Secretory Granule Organization Single Fertilization Protease Binding Serine-type Peptidase Activity Extracellular Region Fertilization Serine-type Endopeptidase Activity	Sarcoplasmic Reticulum Lumen Structural Constituent Of Egg Coat Regulation Of Acrosome Reaction Prevention Of Polyspermy Acrosin Binding Regulation Of Fertilization Egg Coat Negative Regulation Of Protein Autophosphorylation Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Oviduct Epithelium Development Lung Vasculature Development Limb Joint Morphogenesis Uterine Epithelium Development Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Lung Epithelium Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Response To 1-oleoyl-sn-glycerol 3-phosphate Cellular Hyperosmotic Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Response To Platelet-derived Growth Factor Stimulus Uterus Development Regulation Of Protein Tyrosine Kinase Activity Bile Acid Biosynthetic Process Response To Platelet-derived Growth Factor Hyperosmotic Response Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Dexamethasone Stimulus Binding Of Sperm To Zona Pellucida Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of ERBB Signaling Pathway Bile Acid Metabolic Process Response To Progesterone Regulation Of Signaling Receptor Activity Sperm-egg Recognition Regulation Of Collagen Biosynthetic Process Negative Regulation Of Interleukin-1 Production Regulation Of Keratinocyte Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Multivesicular Body Embryo Implantation
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