NPR3 and NFKBIE

		NPR3	NFKBIE
Description		natriuretic peptide receptor 3	NFKB inhibitor epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Protein-containing Complex Extracellular Exosome	Fibrillar Center Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Chloride Ion Binding Peptide Binding Hormone Binding Protein Homodimerization Activity Receptor Decoy Activity	Protein Binding Protein Sequestering Activity
	Biological Process	Skeletal System Development Angiogenesis Blood Vessel Remodeling Osteoclast Proliferation Response To Ischemia CGMP Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Relaxation Of Smooth Muscle
Pathways			Activation of NF-kappaB in B cells
Drugs		Nesiritide
Diseases			Hodgkin lymphoma
GWAS		Appendicular lean mass ( 33097823) Blood pressure ( 21572416 21909110 24954895) Diastolic blood pressure ( 27618452 27841878 26390057 28739976 21909115) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340 28552196 28270201 19570815 23563607 19343178 20881960 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Hypertension ( 31879980 21909115) Mean arterial pressure ( 26390057 30487518 29403010) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Ovarian reserve ( 22116950) Pulse pressure ( 30578418 28739976 27841878) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401) Systolic blood pressure ( 30578418 21909115 27618447 29403010 28739976 28135244 27841878 26390057 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Rheumatoid arthritis ( 22446963 23028356 24390342 30423114 32723749)
Interacting Genes		3 interacting genes: NPPA NPPB NPPC	15 interacting genes: ANKHD1 C1QBP CUL1 HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 PPP6C REL RELA SKP1
Entrez ID		4883	4794
HPRD ID		00167	05181
Ensembl ID		ENSG00000113389	ENSG00000146232
Uniprot IDs		A8K4A5 C9JK69 P17342 Q60I31	O00221 Q7LC14 Q96F31
PDB IDs		1JDN 1JDP 1YK0 1YK1
Enriched GO Terms of Interacting Partners?		Hormone Receptor Binding Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Cyclic Purine Nucleotide Metabolic Process Positive Regulation Of CGMP-mediated Signaling Hormone Activity Regulation Of CGMP-mediated Signaling Purine Ribonucleotide Biosynthetic Process Blood Vessel Diameter Maintenance Cardiac Conduction System Development Regulation Of Tube Size Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Protein Folding Nucleotide Biosynthetic Process Purine-containing Compound Biosynthetic Process Vascular Process In Circulatory System Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Regulation Of Vascular Permeability Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Negative Regulation Of Blood Pressure Nuclear Receptor Binding Circulatory System Process Vasodilation Purine Nucleotide Metabolic Process Cardiac Muscle Tissue Development Signaling Receptor Binding Nucleotide Metabolic Process Negative Regulation Of Collecting Lymphatic Vessel Constriction Diuretic Hormone Activity Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Neuropeptide Signaling Pathway Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Neuropeptide Receptor Binding Response To 3-methylcholanthrene Cumulus Cell Differentiation C-di-GMP Signaling Multicellular Organismal Locomotion Gastric Emptying Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Nucleobase-containing Small Molecule Metabolic Process	Non-canonical NF-kappaB Signal Transduction Defense Response Response To External Biotic Stimulus NF-kappaB P50/p65 Complex Canonical NF-kappaB Signal Transduction Immune System Process I-kappaB/NF-kappaB Complex Immune Response Innate Immune Response NF-kappaB Complex Histone Deacetylase Binding Defense Response To Symbiont Defense Response To Other Organism Response To Lipopolysaccharide Cytosol Inflammatory Response Response To Molecule Of Bacterial Origin Cellular Response To Nicotine Ubiquitin Ligase Complex Scaffold Activity Cellular Response To Lipopolysaccharide Regulation Of Interleukin-12 Production Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of Transcription By RNA Polymerase II Response To Stress Cellular Response To Molecule Of Bacterial Origin Protein Lysine Deacetylase Activity Actinin Binding Nucleoplasm Tissue Remodeling Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Negative Regulation Of Interleukin-12 Production Negative Regulation Of Myotube Differentiation Response To Other Organism Histone Deacetylase Activity Transcription Cis-regulatory Region Binding Response To Interleukin-6 Regulation Of Transcription By RNA Polymerase II Response To Lipid Protein K48-linked Ubiquitination Nucleus Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Sumoylation DNA-binding Transcription Activator Activity Response To Angiotensin Response To Cytokine Response To Muscle Stretch
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